When the molecule you need is not available from stock, or not available at the purity or scale you need, we can arrange its synthesis through partner laboratories whose chemistry and analytical capability we have reviewed. We manage the project, the communication and the documentation so that you deal with one point of contact.
What we can take on
- Research compounds and building blocks for medicinal chemistry, including heterocycles, chiral intermediates and functionalised aromatics.
- Pharmaceutical impurities named in pharmacopoeias or identified in your own stability and process studies.
- Metabolites and degradation products needed as markers in analytical methods.
- Stable-isotope-labelled compounds, such as deuterated internal standards for LC-MS bioanalysis, subject to feasibility.
- Nitrosamine drug substance-related impurities for method development and validation.
From milligrams to scale-up
Most projects start with a feasibility review: we look at the structure, the published or likely route, the availability of starting materials and the analytical requirements, then respond with an indicative route outline, timeline and cost. Typical deliverables range from tens of milligrams of an impurity to multi-kilogram quantities of an intermediate. For scale-up, the route is reviewed for safety, reagent availability and purification practicality, and a demonstration batch usually precedes the full quantity.
Impurity synthesis and characterisation
An impurity standard is only useful if its structure and purity are proven. Depending on the project, characterisation data can include:
- ¹H NMR and, where needed, ¹³C, DEPT or 2D NMR for structural confirmation
- Mass spectrometry (LC-MS or HRMS) for molecular weight and fragmentation
- HPLC chromatographic purity, with the method stated
- IR spectroscopy for functional-group identity
- TGA or Karl Fischer for volatiles and water
- Elemental analysis, specific rotation or chiral HPLC where relevant
We agree the data package before work begins, so there are no surprises at delivery. The package is summarised in a Certificate of Analysis, with the underlying spectra supplied as PDFs.
Confidentiality
We are happy to sign a mutual non-disclosure agreement before you share structures, routes or project details. Structures and project information are shared with the synthesis partner only to the extent needed to perform the work, under equivalent confidentiality obligations. Unless otherwise agreed in writing, compounds made to your specification are supplied only to you.
Starting a project
Send the structure (as a SMILES string, CAS number or drawing), the quantity, the target purity, the analytical data you need and any timeline constraints to query@vaqorachemicals.com. We will reply with questions or a feasibility response.