1-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)thiourea
- CAS
- 2422147-84-8
- Formula
- C8H5F3N4S
- MW
- 246.21 g/mol
VQ-024311
Impurity reference standards
Apalutamide impurities & reference standards
Characterised Apalutamide impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
30reference materials
2isotope-labelled
COAHPLC · NMR · MS on request
Parent API: Apalutamide WS
956104-40-8 · C21H15F4N5O2S
![1-[3-Fluoro-4-(methylcarbamoyl)anilino]cyclobutane-1-carboxylic Acid Triethylamine](/media/pack/1-3-fluoro-4-methylcarbamoylanilinocyclobutane-1-carboxylic-acid-triethylamine.svg?v=3)
1-[3-Fluoro-4-(methylcarbamoyl)anilino]cyclobutane-1-carboxylic Acid Triethylamine
- CAS
- 2408380-70-9
- Formula
- C19H30FN3O3
- MW
- 367.47 g/mol
VQ-035752
1,3-Bis(6-cyano-5-(trifluoromethyl)pyridin-3-yl)thiourea
- CAS
- 2949499-02-7
- Formula
- C15H6F6N6S
- MW
- 416.3 g/mol
VQ-035751
1,3-Bis(6-cyano-5-(trifluoromethyl)pyridin-3-yl)urea
- CAS
- 3031093-12-3
- Formula
- C15H6F6N6O
- MW
- 400.24 g/mol
VQ-035750
4-((1-((6-Cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)amino)-2-fluoro-N-methylbenzamide
- CAS
- 1950587-20-8
- Formula
- C20H17F4N5O2
- MW
- 435.4 g/mol
VQ-024309
4-((1-Cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide
- CAS
- 915087-26-2
- Formula
- C13H14FN3O
- MW
- 247.27 g/mol
VQ-029171
![4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-(1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)benzamide chemical structure](/media/structures/WOOLHYVVBRVTEA-UHFFFAOYSA-N.svg)
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-(1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)benzamide
- CAS
- 2894796-77-9
- Formula
- C40H27F8N9O4S
- MW
- 881.8 g/mol
VQ-035748
![4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-methylbenzamide chemical structure](/media/structures/AXLKZPGGYJJXDF-UHFFFAOYSA-N.svg)
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-methylbenzamide
- CAS
- 1332389-57-7
- Formula
- C21H16F3N5O2S
- MW
- 459.4 g/mol
VQ-024306
Apalutamide Di-(2-fluoro-N-methylbenzamide)
- CAS
- 2894796-76-8
- Formula
- C29H21F5N6O3S
- MW
- 628.6 g/mol
VQ-044637
![Ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate chemical structure](/media/structures/FEGFCONTOHEIDG-UHFFFAOYSA-N.svg)
Ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate
- CAS
- 1332388-83-6
- Formula
- C22H16F4N4O3S
- MW
- 492.4 g/mol
VQ-029174
Methyl 1-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)cyclobutane-1-carboxylate
- CAS
- 2227589-23-1
- Formula
- C14H17FN2O3
- MW
- 280.29 g/mol
VQ-047412
![Methyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate chemical structure](/media/structures/KCBBUMNCDVJYDW-UHFFFAOYSA-N.svg)
Methyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate
- CAS
- 1950587-19-5
- Formula
- C21H14F4N4O3S
- MW
- 478.4 g/mol
VQ-021603
![O-Phenyl (4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoyl)(methyl)carbamothioate chemical structure](/media/structures/UMPURVIVGIHYHO-UHFFFAOYSA-N.svg)
O-Phenyl (4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoyl)(methyl)carbamothioate
- CAS
- 2894796-78-0
- Formula
- C28H19F4N5O3S2
- MW
- 613.6 g/mol
VQ-035749
FAQs — Apalutamide impurities
Which Apalutamide impurities do you supply?
We list 30 Apalutamide-related reference materials, including process impurities, degradation products, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Apalutamide impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Apalutamide impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
Request Apalutamide impurity standards
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