![(1R,2S,5S)-3-((S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid chemical structure](/media/structures/DZIWJAMMMZCSSP-ZDEQEGDKSA-N.svg)
(1R,2S,5S)-3-((S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid
- CAS
- 394735-37-6
- Formula
- C19H32N2O5
- MW
- 368.5 g/mol
VQ-032179
Impurity reference standards
Nirmatrelvir impurities & reference standards
Characterised Nirmatrelvir impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
20reference materials
COAHPLC · NMR · MS on request
![(1R,2S,5S)-3-((S)-2-Amino-3,3-dimethylbutanoyl)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide chemical structure](/media/structures/UGRNCGFEVATDJG-OJFNHCPVSA-N.svg)
(1R,2S,5S)-3-((S)-2-Amino-3,3-dimethylbutanoyl)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
- CAS
- 2883654-28-0
- Formula
- C21H33N5O3
- MW
- 403.5 g/mol
VQ-032176
![(1R,2S,5S)-3-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid chemical structure](/media/structures/JDMCUFJAHAVBLQ-AATLWQCWSA-N.svg)
(1R,2S,5S)-3-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid
- CAS
- 2755812-45-2
- Formula
- C16H23F3N2O4
- MW
- 364.36 g/mol
VQ-032180
![(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile chemical structure](/media/structures/ZLISHYOBWCRHFE-XVMARJQXSA-N.svg)
(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile
- CAS
- 1037559-82-2
- Formula
- C8H12N2
- MW
- 136.19 g/mol
VQ-038663
![(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester hydrochloride chemical structure](/media/structures/FKVUDBWXNAFSPB-MKXDVQRUSA-N.svg)
(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester hydrochloride
- CAS
- 565456-77-1
- Formula
- C9H16ClNO2
- MW
- 205.68 g/mol
VQ-038662
![(1R,2S,5S)-N-((R)-1-Cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide chemical structure](/media/structures/LIENCHBZNNMNKG-PLZKBRGSSA-N.svg)
(1R,2S,5S)-N-((R)-1-Cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
- CAS
- 2755812-41-8
- Formula
- C23H32F3N5O4
- MW
- 499.5 g/mol
VQ-026927
![(1R,2S,5S)-N-((S)-1-Amino-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide chemical structure](/media/structures/OOGWLUVPYYAXCE-WCBJTDJXSA-N.svg)
(1R,2S,5S)-N-((S)-1-Amino-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
- CAS
- 2755812-81-6
- Formula
- C23H34F3N5O5
- MW
- 517.5 g/mol
VQ-026928
![(AS,3S)-a-[(tert-Butyloxycarbonyl)amino]-2-oxo-3-pyrrolidinepropanoic acid Methyl Ester chemical structure](/media/structures/HTQMBOWAEPNWLI-IUCAKERBSA-N.svg)
(AS,3S)-a-[(tert-Butyloxycarbonyl)amino]-2-oxo-3-pyrrolidinepropanoic acid Methyl Ester
- CAS
- 328086-60-8
- Formula
- C13H22N2O5
- MW
- 286.32 g/mol
VQ-044947
(S)-2-Amino-3-((S)-2-oxopyrrolidin-3-yl)propanamide Hydrochloride
- CAS
- 2628280-48-6
- Formula
- C7H14ClN3O2
- MW
- 207.66 g/mol
VQ-026929
(S)-2-Amino-3-((S)-2-oxopyrrolidin-3-yl)propanenitrile Hydrochloride
- CAS
- 2755950-35-5
- Formula
- C7H12ClN3O
- MW
- 189.64 g/mol
VQ-038661
(S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butanoic acid
- CAS
- 666832-71-9
- Formula
- C8H12F3NO3
- MW
- 227.18 g/mol
VQ-044248
![Methyl (1R,2R,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate chemical structure](/media/structures/KCIDWDVSBWPHLH-LYFYHCNISA-N.svg)
Methyl (1R,2R,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
- CAS
- 1932411-98-7
- Formula
- C9H15NO2
- MW
- 169.22 g/mol
VQ-032181
![Methyl (1S,2R,5R)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate chemical structure](/media/structures/KCIDWDVSBWPHLH-FSDSQADBSA-N.svg)
Methyl (1S,2R,5R)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
- CAS
- 943516-62-9
- Formula
- C9H15NO2
- MW
- 169.22 g/mol
VQ-032178
![Methyl (1S,2S,5R)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate chemical structure](/media/structures/KCIDWDVSBWPHLH-QYNIQEEDSA-N.svg)
Methyl (1S,2S,5R)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
- CAS
- 1932478-97-1
- Formula
- C9H15NO2
- MW
- 169.22 g/mol
VQ-044249
Methyl (S)-2-amino-3-((S)-2-oxopyrrolidin-3-yl)propanoate
- CAS
- 1027601-37-1
- Formula
- C8H14N2O3
- MW
- 186.21 g/mol
VQ-044315
Methyl(S)-2-amino-3-((S)-2-oxopyrrolidin-3-yl)propanoate hydrochloride
- CAS
- 1429218-41-6
- Formula
- C8H15ClN2O3
- MW
- 222.67 g/mol
VQ-032177
FAQs — Nirmatrelvir impurities
Which Nirmatrelvir impurities do you supply?
We list 20 Nirmatrelvir-related reference materials, including process impurities, degradation products and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Nirmatrelvir impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Nirmatrelvir impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
Request Nirmatrelvir impurity standards
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