1-(4-Chlorophenyl)biguanide Hydrochloride

Name: 1-(4-Chlorophenyl)biguanide Hydrochloride
Brand: Vaqora Chemicals
SKU: VQ-036243

About 1-(4-Chlorophenyl)biguanide Hydrochloride

Listed under CAS 4022-81-5, 1-(4-Chlorophenyl)biguanide Hydrochloride is a process intermediate or related compound of Chlorhexidine available from Vaqora Chemicals. The compound has the formula C8H11Cl2N5, corresponding to a molecular weight of 248.11 g/mol. Common synonyms include 4-Chlorophenylbiguanide Hydrochloride and 1-(p-Chlorophenyl)biguanide hydrochloride.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

It is a process intermediate or related compound in the synthesis of Chlorhexidine, useful for route development, impurity fate-and-purge studies and analytical method development. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development
Fine chemical synthesis

Industries

Related to Chlorhexidine

View every impurity, metabolite and intermediate we list for Chlorhexidine.

Chlorhexidine impurities

Specifications & identifiers

Chemical identifiers
Product name	1-(4-Chlorophenyl)biguanide Hydrochloride
Catalogue No.	VQ-036243
CAS Number	4022-81-5
IUPAC name	2-(4-chlorophenyl)-1-(diaminomethylidene)guanidine;hydrochloride
Molecular formula	C₈H₁₁Cl₂N₅
Molecular weight	248.11 g/mol
Exact mass	247.0392
HSN code	2933
InChIKey	NAFSLMFLGYXGIF-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1N=C(N)N=C(N)N)Cl.Cl
PubChem CID	458746

Physical properties
Physical form	Solid
H-bond donors / acceptors	4 / 1
TPSA	103 Å²
Synonyms	4-Chlorophenylbiguanide Hydrochloride, 1-(p-Chlorophenyl)biguanide hydrochloride, N-(p-Chlorophenyl) biguanide hydrochloride, N-(4-Chlorophenyl)-imidocarbonimidic diamide monohydrochloride, Biguanide, 1-(p-chlorophenyl)-, hydrochloride, BIGUANIDE, 1-(p-CHLOROPHENYL)-, MONOHYDROCHLORIDE, Imidodicarbonimidic diamide, N-(4-chlorophenyl)-, monohydrochloride, 1-carbamimidamido-N-(4-chlorophenyl)methanimidamide hydrochloride, N-(4-chlorophenyl)imidodicarbonimidic diamide hydrochloride, 1-carbamimidoyl-3-(4-chlorophenyl)guanidine, 1-(4-Chlorophenyl)biguanide, HCl, p-chlorophenylbiguanide hydrochloride

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-(4-Chlorophenyl)biguanide Hydrochloride?

The CAS Registry Number of 1-(4-Chlorophenyl)biguanide Hydrochloride is 4022-81-5. It is also known as 4-Chlorophenylbiguanide Hydrochloride, 1-(p-Chlorophenyl)biguanide hydrochloride, N-(p-Chlorophenyl) biguanide hydrochloride.

What is the molecular formula and molecular weight of 1-(4-Chlorophenyl)biguanide Hydrochloride?

1-(4-Chlorophenyl)biguanide Hydrochloride has the molecular formula C8H11Cl2N5 and a molecular weight of 248.11 g/mol.

What is 1-(4-Chlorophenyl)biguanide Hydrochloride used for?

1-(4-Chlorophenyl)biguanide Hydrochloride is supplied as a characterised reference material related to Chlorhexidine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-(4-Chlorophenyl)biguanide Hydrochloride can I order?

We supply 1-(4-Chlorophenyl)biguanide Hydrochloride, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-(4-Chlorophenyl)biguanide Hydrochloride?

Yes. Every lot of 1-(4-Chlorophenyl)biguanide Hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-(4-Chlorophenyl)biguanide Hydrochloride be shipped internationally?

Yes. 1-(4-Chlorophenyl)biguanide Hydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.