1-Chloro-4-isocyanato-2-(trifluoromethyl)benz… 327-78-6

Name: 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene
Brand: Vaqora Chemicals
SKU: VQ-039471

About 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene

1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene is an impurity of Sorafenib carrying the CAS registry number 327-78-6. With the molecular formula C8H3ClF3NO, it has a molar mass of 221.56 g/mol. Alternative names: 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate and 4-Chloro-3-(trifluoromethyl)phenylisocyanate.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Sorafenib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sorafenib

View every impurity, metabolite and intermediate we list for Sorafenib.

Sorafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene
Catalogue No.	VQ-039471
CAS Number	327-78-6
IUPAC name	1-chloro-4-isocyanato-2-(trifluoromethyl)benzene
Molecular formula	C₈H₃ClF₃NO
Molecular weight	221.56 g/mol
Exact mass	220.9855
Grade	Reference Standard
HSN code	38229090
InChIKey	NBJZEUQTGLSUOB-UHFFFAOYSA-N
SMILES	C1=CC(=C(C=C1N=C=O)C(F)(F)F)Cl
PubChem CID	2733265

Physical properties
Physical form	Solid
LogP (XLogP3)	5
H-bond donors / acceptors	0 / 5
TPSA	29.4 Å²
Synonyms	4-Chloro-3-(trifluoromethyl)phenyl Isocyanate, 4-Chloro-3-(trifluoromethyl)phenylisocyanate, 4-chloro-3-(trifluoromethyl)benzenisocyanate, CS-M2757, 4-chloro-3-trifluoromethyphenylisocyanate, 3-trifluoromethyl-4-chlorophenylisocyanate, 4-chloro-3-trifluoromethylphenylisocyanate, 4chloro-3-trifluoromethylphenyl isocyanate, 3-trifluoromethyl- 4-chlorophenylisocyanate, 3-trifluoromethyl-4-chloro-phenylisocyanate, 3-trifluoromethyl-4-chlorophenyl isocyanate

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation

Precautionary statements: P233, P260, P261, P264, P264 + P265, P270, P271, P280, P284, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P342 + P316, P362 + P364, P403, P403 + P233, P405

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene?

The CAS Registry Number of 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene is 327-78-6. It is also known as 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate, 4-Chloro-3-(trifluoromethyl)phenylisocyanate, 4-chloro-3-(trifluoromethyl)benzenisocyanate.

What is the molecular formula and molecular weight of 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene?

1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene has the molecular formula C8H3ClF3NO and a molecular weight of 221.56 g/mol. Its IUPAC name is 1-chloro-4-isocyanato-2-(trifluoromethyl)benzene.

What is 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene used for?

1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene is supplied as a characterised reference material related to Sorafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene can I order?

We supply 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene?

Yes. Every lot of 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene be shipped internationally?

Yes. 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.