1-Methyl-4-(6-aminopyridin-3-yl)piperazine

Name: 1-Methyl-4-(6-aminopyridin-3-yl)piperazine
Brand: Vaqora Chemicals
SKU: VQ-032935

About 1-Methyl-4-(6-aminopyridin-3-yl)piperazine

Vaqora Chemicals supplies 1-Methyl-4-(6-aminopyridin-3-yl)piperazine, a process intermediate or related compound of Trilaciclib registered under CAS number 571189-49-6. Its molecular formula is C10H16N4 and its molecular weight is 192.26 g/mol. The IUPAC name is 5-(4-methylpiperazin-1-yl)pyridin-2-amine. Alternative names: 5-(4-methyl-piperazin-1-yl)-pyridin-2-ylamine and 2-Pyridinamine, 5-(4-methyl-1-piperazinyl)-.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 11 hazard statements. Review the Safety Data Sheet before use.

Process chemists and analysts use it when developing synthetic routes to Trilaciclib, tracking process-related impurities and validating analytical methods. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 1-Methyl-4-(6-aminopyridin-3-yl)piperazine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development
Fine chemical synthesis

Industries

Related to Trilaciclib

View every impurity, metabolite and intermediate we list for Trilaciclib.

Trilaciclib impurities

Specifications & identifiers

Chemical identifiers
Product name	1-Methyl-4-(6-aminopyridin-3-yl)piperazine
Catalogue No.	VQ-032935
CAS Number	571189-49-6
IUPAC name	5-(4-methylpiperazin-1-yl)pyridin-2-amine
Molecular formula	C₁₀H₁₆N₄
Molecular weight	192.26 g/mol
Exact mass	192.1375
HSN code	2933
InChIKey	QDMPMBFLXOWHRY-UHFFFAOYSA-N
SMILES	CN1CCN(CC1)C2=CN=C(C=C2)N
PubChem CID	22329833

Physical properties
Physical form	Solid
LogP (XLogP3)	0.4
H-bond donors / acceptors	1 / 4
TPSA	45.4 Å²
Synonyms	5-(4-methyl-piperazin-1-yl)-pyridin-2-ylamine, 2-Pyridinamine, 5-(4-methyl-1-piperazinyl)-, 2-Amino-5-(4-methyl-1-piperazinyl)pyridine, 5-(4-methylpiperazin-1-yl)pyridin-2--amine, 5-(4-methyl-1-piperazinyl)-2-pyridinamine, CS-M3136, 5-(4-methylpiperazin-1-yl)piridin-2-amine, 1-Methyl-4-(6-aminopyridin-3-yl)piperazine, AldrichCPR

Safety & hazard information (GHS)

Corrosive

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H412Harmful to aquatic life with long lasting effects

Precautionary statements: P203, P260, P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P316, P301 + P317, P301 + P330 + P331, P302 + P352, P302 + P361 + P354, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P316, P317, P318, P319, P321, P330, P332 + P317

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-Methyl-4-(6-aminopyridin-3-yl)piperazine?

The CAS Registry Number of 1-Methyl-4-(6-aminopyridin-3-yl)piperazine is 571189-49-6. It is also known as 5-(4-methyl-piperazin-1-yl)-pyridin-2-ylamine, 2-Pyridinamine, 5-(4-methyl-1-piperazinyl)-, 2-Amino-5-(4-methyl-1-piperazinyl)pyridine.

What is the molecular formula and molecular weight of 1-Methyl-4-(6-aminopyridin-3-yl)piperazine?

1-Methyl-4-(6-aminopyridin-3-yl)piperazine has the molecular formula C10H16N4 and a molecular weight of 192.26 g/mol. Its IUPAC name is 5-(4-methylpiperazin-1-yl)pyridin-2-amine.

What is 1-Methyl-4-(6-aminopyridin-3-yl)piperazine used for?

1-Methyl-4-(6-aminopyridin-3-yl)piperazine is supplied as a characterised reference material related to Trilaciclib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-Methyl-4-(6-aminopyridin-3-yl)piperazine can I order?

We supply 1-Methyl-4-(6-aminopyridin-3-yl)piperazine, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-Methyl-4-(6-aminopyridin-3-yl)piperazine?

Yes. Every lot of 1-Methyl-4-(6-aminopyridin-3-yl)piperazine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-Methyl-4-(6-aminopyridin-3-yl)piperazine be shipped internationally?

Yes. 1-Methyl-4-(6-aminopyridin-3-yl)piperazine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.