11α,17,21-Trihydroxy-16α-methylpregna-1,4-die… 78761-59-8

Name: 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
Brand: Vaqora Chemicals
SKU: VQ-043135

About 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione

Listed under CAS 78761-59-8, 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione is an impurity of Dexamethasone available from Vaqora Chemicals. Formula C22H30O5, molecular weight 374.5 g/mol.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

This Dexamethasone impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. SDS and detailed specification sheets can be requested with your quotation.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Dexamethasone

View every impurity, metabolite and intermediate we list for Dexamethasone.

Dexamethasone impurities

Specifications & identifiers

Chemical identifiers
Product name	11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
Catalogue No.	VQ-043135
CAS Number	78761-59-8
IUPAC name	(8S,9S,10R,11R,13S,14S,16R,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Molecular formula	C₂₂H₃₀O₅
Molecular weight	374.5 g/mol
Exact mass	374.2093
Grade	Reference Standard
HSN code	38229090
InChIKey	WNYLPFCKNQAAMB-JPDWDDBRSA-N
SMILES	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@H]3[C@@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C
PubChem CID	11314822

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	3 / 5
TPSA	94.8 Å²
Synonyms	11alpha,17alpha,21-Trihydroxy-16alpha-methyl-1,4-pregnadiene-3,20-dione, 11alpha,17,21-Trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione, (11alpha,16alpha)-11,17,21-Trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 11a,17a,21-Trihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione, 11I+/-,17I+/-,21-Trihydroxy-16I+/--methyl-1,4-pregnadiene-3,20-dione, (11OE+/-,16OE+/-)-11,17,21-Trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 1OE+/-,17OE+/-,21-Trihydroxy-16OE+/--methyl-1,4-pregnadiene-3,20-dione

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P280, P318, P319, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione?

The CAS Registry Number of 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione is 78761-59-8. It is also known as 11alpha,17alpha,21-Trihydroxy-16alpha-methyl-1,4-pregnadiene-3,20-dione, 11alpha,17,21-Trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione, (11alpha,16alpha)-11,17,21-Trihydroxy-16-methylpregna-1,4-diene-3,20-dione.

What is the molecular formula and molecular weight of 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione?

11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione has the molecular formula C22H30O5 and a molecular weight of 374.5 g/mol. Its IUPAC name is (8S,9S,10R,11R,13S,14S,16R,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one.

What is 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione used for?

11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione is supplied as a characterised reference material related to Dexamethasone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione can I order?

We supply 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione?

Yes. Every lot of 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione be shipped internationally?

Yes. 11α,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.