(1S,2S)-Nicotine 1-Oxide

Name: (1S,2S)-Nicotine 1-Oxide
Brand: Vaqora Chemicals
SKU: VQ-032136

About (1S,2S)-Nicotine 1-Oxide

Vaqora Chemicals supplies (1S,2S)-Nicotine 1-Oxide, an impurity of Nicotine registered under CAS number 51095-86-4. The compound has the formula C10H14N2O, corresponding to a molecular weight of 178.23 g/mol. The IUPAC name is 3-[(1S,2S)-1-methyl-1-oxidopyrrolidin-1-ium-2-yl]pyridine. It is also known as Nicotine-cis-N-oxide or (1S,2S)-syn-Nicotine N'-oxide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

This Nicotine impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, (1S,2S)-Nicotine 1-Oxide is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Nicotine

View every impurity, metabolite and intermediate we list for Nicotine.

Nicotine impurities

Specifications & identifiers

Chemical identifiers
Product name	(1S,2S)-Nicotine 1-Oxide
Catalogue No.	VQ-032136
CAS Number	51095-86-4
IUPAC name	3-[(1S,2S)-1-methyl-1-oxidopyrrolidin-1-ium-2-yl]pyridine
Molecular formula	C₁₀H₁₄N₂O
Molecular weight	178.23 g/mol
Exact mass	178.1106
Grade	Reference Standard
HSN code	38229090
InChIKey	RWFBQHICRCUQJJ-JQWIXIFHSA-N
SMILES	C[N@@+]1(CCC[C@H]1C2=CN=CC=C2)[O-]
PubChem CID	12313859

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	0 / 2
TPSA	31 Å²
Synonyms	Nicotine-cis-N-oxide, (1S,2S)-1-Methyl-2-(pyridin-3-yl)pyrrolidine 1-oxide, 3-((1S,2S)-1-Methyl-1-oxido-2-pyrrolidinyl)pyridine, (1S,2S)-syn-Nicotine N'-oxide, Nicotine-cis-N-oxide, (+)-, (1'S,2'S)-trans-Nicotine-1'-N-oxide, rac-Nicotine-1'-oxide, Nicotine N'-oxide, (1'S,2'S)-

Safety & hazard information (GHS)

Corrosive

Toxic

Harmful / irritant

Environmental hazard

Signal word: Danger

Hazard statements

H300+H310+H330Fatal if swallowed, in contact with skin or if inhaled
H300Fatal if swallowed
H301Toxic if swallowed
H310Fatal in contact with skin
H311Toxic in contact with skin
H315Causes skin irritation
H318Causes serious eye damage
H330Fatal if inhaled
H331Toxic if inhaled
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P260, P261, P262, P264, P264 + P265, P270, P271, P273, P280, P284, P301 + P316, P302 + P352, P304 + P340, P305 + P354 + P338, P316, P317, P320, P321, P330, P332 + P317, P361 + P364, P362 + P364, P391, P403 + P233

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (1S,2S)-Nicotine 1-Oxide?

The CAS Registry Number of (1S,2S)-Nicotine 1-Oxide is 51095-86-4. It is also known as Nicotine-cis-N-oxide, (1S,2S)-1-Methyl-2-(pyridin-3-yl)pyrrolidine 1-oxide, 3-((1S,2S)-1-Methyl-1-oxido-2-pyrrolidinyl)pyridine.

What is the molecular formula and molecular weight of (1S,2S)-Nicotine 1-Oxide?

(1S,2S)-Nicotine 1-Oxide has the molecular formula C10H14N2O and a molecular weight of 178.23 g/mol. Its IUPAC name is 3-[(1S,2S)-1-methyl-1-oxidopyrrolidin-1-ium-2-yl]pyridine.

What is (1S,2S)-Nicotine 1-Oxide used for?

(1S,2S)-Nicotine 1-Oxide is supplied as a characterised reference material related to Nicotine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (1S,2S)-Nicotine 1-Oxide can I order?

We supply (1S,2S)-Nicotine 1-Oxide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (1S,2S)-Nicotine 1-Oxide?

Yes. Every lot of (1S,2S)-Nicotine 1-Oxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (1S,2S)-Nicotine 1-Oxide be shipped internationally?

Yes. (1S,2S)-Nicotine 1-Oxide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.