(1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-… 480449-84-1

Name: (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester
Brand: Vaqora Chemicals
SKU: VQ-036875

About (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester

(1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester is an impurity of Edoxaban carrying the CAS registry number 480449-84-1. Its molecular formula is C14H26N2O4 and its molecular weight is 286.37 g/mol. The IUPAC name is ethyl (1S,3R,4S)-4-amino-3-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylate.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 4 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Edoxaban to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Edoxaban

View every impurity, metabolite and intermediate we list for Edoxaban.

Edoxaban impurities

Specifications & identifiers

Chemical identifiers
Product name	(1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester
Catalogue No.	VQ-036875
CAS Number	480449-84-1
IUPAC name	ethyl (1S,3R,4S)-4-amino-3-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylate
Molecular formula	C₁₄H₂₆N₂O₄
Molecular weight	286.37 g/mol
Exact mass	286.1893
Grade	Reference Standard
HSN code	38229090
InChIKey	STWAQGKVYHZJCJ-GARJFASQSA-N
SMILES	CCOC(=O)[C@H]1CC[C@@H]([C@@H](C1)NC(=O)OC(C)(C)C)N
PubChem CID	16005245

Physical properties
Physical form	Solid
LogP (XLogP3)	1.2
H-bond donors / acceptors	2 / 5
TPSA	90.7 Å²
Synonyms	Ethyl (1S,3R,4S)-4-amino-3-{[(tert-butoxy)carbonyl]amino}cyclohexane-1-carboxylate, ethyl (1S,3R,4S)-4-amino-3-(((tert-butoxy)carbonyl)amino)cyclohexane-1-carboxylate, (1S,3R,4S)-Ethyl 4-amino-3-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate, (1S,3R,4S)-ethyl 4-aMino-3-(tert-butoxycarbonylaMino)cyclohexanecarboxylate, ethyl (1S,3R,4S)-4-amino-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate, Ethyl (1S,3R,4S)-4-amino-3-[(tert-butoxycarbonyl)amino]cyclohexane-1-carboxylate, (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexanecarboxylicacidethylester-A13801, (1S,2R,4S)-N2-tert-Butoxycarbonyl-4-ethoxycarbonyl-1,2-cyclohexanediamine, (1S,3R,4S)-Ethyl4-amino-3-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate, ethyl (1S,3R,4S)-4-amino-3-(tert-butoxycarbonylamino)cyclohexanecarboxylate

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P319, P321, P330, P332 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester?

The CAS Registry Number of (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester is 480449-84-1. It is also known as Ethyl (1S,3R,4S)-4-amino-3-{[(tert-butoxy)carbonyl]amino}cyclohexane-1-carboxylate, ethyl (1S,3R,4S)-4-amino-3-(((tert-butoxy)carbonyl)amino)cyclohexane-1-carboxylate, (1S,3R,4S)-Ethyl 4-amino-3-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate.

What is the molecular formula and molecular weight of (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester?

(1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester has the molecular formula C14H26N2O4 and a molecular weight of 286.37 g/mol. Its IUPAC name is ethyl (1S,3R,4S)-4-amino-3-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylate.

What is (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester used for?

(1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester is supplied as a characterised reference material related to Edoxaban. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester can I order?

We supply (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester?

Yes. Every lot of (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester be shipped internationally?

Yes. (1S,3R,4S)-4-Amino-3-(Boc-amino)-cyclohexane-carboxylic acid ethyl ester is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.