2-Acetyl-5-chlorothiophene

Name: 2-Acetyl-5-chlorothiophene
Brand: Vaqora Chemicals
SKU: VQ-041946

About 2-Acetyl-5-chlorothiophene

Listed under CAS 6310-09-4, 2-Acetyl-5-chlorothiophene is an impurity of Rivaroxaban available from Vaqora Chemicals. With the molecular formula C6H5ClOS, it has a molar mass of 160.62 g/mol. The IUPAC name is 1-(5-chlorothiophen-2-yl)ethanone. Common synonyms include 1-(5-Chloro-2-thienyl)ethanone and 5-Chloro-2-acetylthiophene.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 6 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Rivaroxaban to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer 2-Acetyl-5-chlorothiophene in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Rivaroxaban

View every impurity, metabolite and intermediate we list for Rivaroxaban.

Rivaroxaban impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Acetyl-5-chlorothiophene
Catalogue No.	VQ-041946
CAS Number	6310-09-4
IUPAC name	1-(5-chlorothiophen-2-yl)ethanone
Molecular formula	C₆H₅ClOS
Molecular weight	160.62 g/mol
Exact mass	159.975
Grade	Reference Standard
HSN code	38229090
InChIKey	HTZGPEHWQCRXGZ-UHFFFAOYSA-N
SMILES	CC(=O)C1=CC=C(S1)Cl
PubChem CID	80572

Physical properties
Physical form	Solid
LogP (XLogP3)	2.6
H-bond donors / acceptors	0 / 2
TPSA	45.3 Å²
Synonyms	1-(5-Chloro-2-thienyl)ethanone, 5-Chloro-2-acetylthiophene, 5-Chloro-2-thienyl methyl ketone, 2-Chloro-5-acetylthiophene, Ketone, 5-chloro-2-thienyl methyl, Ethanone, 1-(5-chloro-2-thienyl)-, 5-Chlor-2-acetyl thiophen, 1-(5-chlorothiophen-2-yl)ethan-1-one, 5-Chloro-2-acetyl thiophen, 1-(5-Chloro-2-thienyl)ethan-1-one, 1-(5-chlorothien-2-yl)ethanone, 1-(5-chloro-2-thienyl)-1-ethanone

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H300Fatal if swallowed
H301Toxic if swallowed
H302Harmful if swallowed
H312Harmful in contact with skin
H319Causes serious eye irritation
H332Harmful if inhaled

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P321, P330, P337 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Acetyl-5-chlorothiophene?

The CAS Registry Number of 2-Acetyl-5-chlorothiophene is 6310-09-4. It is also known as 1-(5-Chloro-2-thienyl)ethanone, 5-Chloro-2-acetylthiophene, 5-Chloro-2-thienyl methyl ketone.

What is the molecular formula and molecular weight of 2-Acetyl-5-chlorothiophene?

2-Acetyl-5-chlorothiophene has the molecular formula C6H5ClOS and a molecular weight of 160.62 g/mol. Its IUPAC name is 1-(5-chlorothiophen-2-yl)ethanone.

What is 2-Acetyl-5-chlorothiophene used for?

2-Acetyl-5-chlorothiophene is supplied as a characterised reference material related to Rivaroxaban. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Acetyl-5-chlorothiophene can I order?

We supply 2-Acetyl-5-chlorothiophene in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Acetyl-5-chlorothiophene?

Yes. Every lot of 2-Acetyl-5-chlorothiophene is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Acetyl-5-chlorothiophene be shipped internationally?

Yes. 2-Acetyl-5-chlorothiophene is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.