2-Amino-5-nitroso-4,6-pyrimidinediol

Name: 2-Amino-5-nitroso-4,6-pyrimidinediol
Brand: Vaqora Chemicals
SKU: VQ-035713

About 2-Amino-5-nitroso-4,6-pyrimidinediol

Vaqora Chemicals supplies 2-Amino-5-nitroso-4,6-pyrimidinediol, a nitrosamine impurity of Amoxicillin registered under CAS number 55482-22-9. With the molecular formula C4H4N4O3, it has a molar mass of 156.1 g/mol. Systematically, it is named 2-amino-4-hydroxy-5-nitroso-1H-pyrimidin-6-one. It is also known as 4,6-Pyrimidinediol, 2-amino-5-nitroso-.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 2-Amino-5-nitroso-4,6-pyrimidinediol in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Amoxicillin

View every impurity, metabolite and intermediate we list for Amoxicillin.

Amoxicillin impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Amino-5-nitroso-4,6-pyrimidinediol
Catalogue No.	VQ-035713
CAS Number	55482-22-9
IUPAC name	2-amino-4-hydroxy-5-nitroso-1H-pyrimidin-6-one
Molecular formula	C₄H₄N₄O₃
Molecular weight	156.1 g/mol
Exact mass	156.0283
Grade	Reference Standard
HSN code	38229090
InChIKey	NXTPQVKFPBRMRH-UHFFFAOYSA-N
SMILES	C1(=C(N=C(NC1=O)N)O)N=O
PubChem CID	263075

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.3
H-bond donors / acceptors	3 / 5
TPSA	117 Å²
Synonyms	2-Amino-6-hydroxy-5-nitrosopyrimidin-4(3H)-one, 2-Iminodihydro-4,5,6(1H)-pyrimidinetrione 5-oxime, 4,6-Pyrimidinediol, 2-amino-5-nitroso-, 5-hydroxyimino-2-imino-hexahydropyrimidine-4,6-dione, 2-amino-6-hydroxy-5-nitroso-3,4-dihydropyrimidin-4-one, 5-(Hydroxyimino)-2-imino-2,5-dihydropyrimidine-4,6-diol

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation

Precautionary statements: P261, P264, P264 + P265, P270, P272, P280, P301 + P317, P302 + P352, P305 + P351 + P338, P321, P330, P333 + P317, P337 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Amino-5-nitroso-4,6-pyrimidinediol?

The CAS Registry Number of 2-Amino-5-nitroso-4,6-pyrimidinediol is 55482-22-9. It is also known as 2-Amino-6-hydroxy-5-nitrosopyrimidin-4(3H)-one, 2-Iminodihydro-4,5,6(1H)-pyrimidinetrione 5-oxime, 4,6-Pyrimidinediol, 2-amino-5-nitroso-.

What is the molecular formula and molecular weight of 2-Amino-5-nitroso-4,6-pyrimidinediol?

2-Amino-5-nitroso-4,6-pyrimidinediol has the molecular formula C4H4N4O3 and a molecular weight of 156.1 g/mol. Its IUPAC name is 2-amino-4-hydroxy-5-nitroso-1H-pyrimidin-6-one.

What is 2-Amino-5-nitroso-4,6-pyrimidinediol used for?

2-Amino-5-nitroso-4,6-pyrimidinediol is supplied as a characterised reference material related to Amoxicillin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Amino-5-nitroso-4,6-pyrimidinediol can I order?

We supply 2-Amino-5-nitroso-4,6-pyrimidinediol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Amino-5-nitroso-4,6-pyrimidinediol?

Yes. Every lot of 2-Amino-5-nitroso-4,6-pyrimidinediol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Amino-5-nitroso-4,6-pyrimidinediol be shipped internationally?

Yes. 2-Amino-5-nitroso-4,6-pyrimidinediol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.