2-Bromo-2′,5′-dimethoxyacetophenone

Name: 2-Bromo-2′,5′-dimethoxyacetophenone
Brand: Vaqora Chemicals
SKU: VQ-026687

About 2-Bromo-2′,5′-dimethoxyacetophenone

2-Bromo-2′,5′-dimethoxyacetophenone is an impurity of Midodrine carrying the CAS registry number 1204-21-3. Its molecular formula is C10H11BrO3 and its molecular weight is 259.1 g/mol. Systematically, it is named 2-bromo-1-(2,5-dimethoxyphenyl)ethanone. Alternative names: Ethanone, 2-bromo-1-(2,5-dimethoxyphenyl)- and 2,5-Dimethoxyphenacyl bromide.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Midodrine to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 2-Bromo-2′,5′-dimethoxyacetophenone is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Midodrine

View every impurity, metabolite and intermediate we list for Midodrine.

Midodrine impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Bromo-2′,5′-dimethoxyacetophenone
Catalogue No.	VQ-026687
CAS Number	1204-21-3
IUPAC name	2-bromo-1-(2,5-dimethoxyphenyl)ethanone
Molecular formula	C₁₀H₁₁BrO₃
Molecular weight	259.1 g/mol
Exact mass	257.9892
Grade	Reference Standard
HSN code	38229090
InChIKey	RGQNFYVSEWDUEI-UHFFFAOYSA-N
SMILES	COC1=CC(=C(C=C1)OC)C(=O)CBr
PubChem CID	70997

Physical properties
Physical form	Solid
LogP (XLogP3)	2.3
H-bond donors / acceptors	0 / 3
TPSA	35.5 Å²
Synonyms	Ethanone, 2-bromo-1-(2,5-dimethoxyphenyl)-, 2,5-Dimethoxyphenacyl bromide, alpha-Bromo-2',5'-dimethoxyacetophenone, .alpha.-Bromo-2',5'-dimethoxy acetophenone, alpha-bromo-2,5-dimethoxyacetophenone, alpha-Bromo-2',5'-dimethoxy acetophenone, 2-Bromo-1-(2,5-dimethoxyphenyl)ethan-1-one, 1-(2,5-dimethoxyphenyl)-2-bromoethan-1-one

Safety & hazard information (GHS)

Harmful / irritant

Environmental hazard

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H400Very toxic to aquatic life

Precautionary statements: P261, P264, P264 + P265, P271, P273, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P391, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Bromo-2′,5′-dimethoxyacetophenone?

The CAS Registry Number of 2-Bromo-2′,5′-dimethoxyacetophenone is 1204-21-3. It is also known as Ethanone, 2-bromo-1-(2,5-dimethoxyphenyl)-, 2,5-Dimethoxyphenacyl bromide, alpha-Bromo-2',5'-dimethoxyacetophenone.

What is the molecular formula and molecular weight of 2-Bromo-2′,5′-dimethoxyacetophenone?

2-Bromo-2′,5′-dimethoxyacetophenone has the molecular formula C10H11BrO3 and a molecular weight of 259.1 g/mol. Its IUPAC name is 2-bromo-1-(2,5-dimethoxyphenyl)ethanone.

What is 2-Bromo-2′,5′-dimethoxyacetophenone used for?

2-Bromo-2′,5′-dimethoxyacetophenone is supplied as a characterised reference material related to Midodrine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Bromo-2′,5′-dimethoxyacetophenone can I order?

We supply 2-Bromo-2′,5′-dimethoxyacetophenone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Bromo-2′,5′-dimethoxyacetophenone?

Yes. Every lot of 2-Bromo-2′,5′-dimethoxyacetophenone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Bromo-2′,5′-dimethoxyacetophenone be shipped internationally?

Yes. 2-Bromo-2′,5′-dimethoxyacetophenone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.