2-Chloro Adenosine

Name: 2-Chloro Adenosine
Brand: Vaqora Chemicals
SKU: VQ-033480

About 2-Chloro Adenosine

2-Chloro Adenosine (CAS 146-77-0) is an impurity of Regadenoson offered by Vaqora Chemicals. The compound has the formula C10H12ClN5O4, corresponding to a molecular weight of 301.69 g/mol. The IUPAC name is (2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol. It is also known as 2-Chloroadenosinehemihydrate or 6-Amino-2-chloropurine riboside.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 9 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Regadenoson to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 2-Chloro Adenosine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Regadenoson

View every impurity, metabolite and intermediate we list for Regadenoson.

Regadenoson impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Chloro Adenosine
Catalogue No.	VQ-033480
CAS Number	146-77-0
IUPAC name	(2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Molecular formula	C₁₀H₁₂ClN₅O₄
Molecular weight	301.69 g/mol
Exact mass	301.0578
Grade	Reference Standard
HSN code	38229090
InChIKey	BIXYYZIIJIXVFW-UUOKFMHZSA-N
SMILES	C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)Cl)N
PubChem CID	8974

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.1
H-bond donors / acceptors	4 / 8
TPSA	140 Å²
Synonyms	2-Chloroadenosinehemihydrate, 6-Amino-2-chloropurine riboside, 5-Chloroformycin A, (2R,3R,4S,5R)-2-(6-amino-2-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, 2-CADO, 2-chloro[3h]adenosine, Cl-Ado, Opera_ID_460, (2R,3R,4S,5R)-2-(6-amino-2-chloro-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5R)-2-(6-amino-2-chloro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Chloro Adenosine?

The CAS Registry Number of 2-Chloro Adenosine is 146-77-0. It is also known as 2-Chloroadenosinehemihydrate, 6-Amino-2-chloropurine riboside, 5-Chloroformycin A.

What is the molecular formula and molecular weight of 2-Chloro Adenosine?

2-Chloro Adenosine has the molecular formula C10H12ClN5O4 and a molecular weight of 301.69 g/mol. Its IUPAC name is (2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol.

What is 2-Chloro Adenosine used for?

2-Chloro Adenosine is supplied as a characterised reference material related to Regadenoson. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Chloro Adenosine can I order?

We supply 2-Chloro Adenosine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Chloro Adenosine?

Yes. Every lot of 2-Chloro Adenosine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Chloro Adenosine be shipped internationally?

Yes. 2-Chloro Adenosine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.