2-(Dicyclohexylphosphino)-2'-methylbiphenyl 251320-86-2

Name: 2-(Dicyclohexylphosphino)-2'-methylbiphenyl
Brand: Vaqora Chemicals
SKU: VQ-048925

About 2-(Dicyclohexylphosphino)-2'-methylbiphenyl

2-(Dicyclohexylphosphino)-2'-methylbiphenyl (CAS 251320-86-2) is a process intermediate or related compound of Loperamide offered by Vaqora Chemicals. Its molecular formula is C25H33P and its molecular weight is 364.5 g/mol. Its systematic (IUPAC) name is dicyclohexyl-[2-(2-methylphenyl)phenyl]phosphane. Common synonyms include dicyclohexyl-[2-(o-tolyl)phenyl]phosphane and Dicyclohexyl(2'-methyl-2-biphenylyl)phosphine.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

It is a process intermediate or related compound in the synthesis of Loperamide, useful for route development, impurity fate-and-purge studies and analytical method development. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 2-(Dicyclohexylphosphino)-2'-methylbiphenyl is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Loperamide

View every impurity, metabolite and intermediate we list for Loperamide.

Loperamide impurities

Specifications & identifiers

Chemical identifiers
Product name	2-(Dicyclohexylphosphino)-2'-methylbiphenyl
Catalogue No.	VQ-048925
CAS Number	251320-86-2
IUPAC name	dicyclohexyl-[2-(2-methylphenyl)phenyl]phosphane
Molecular formula	C₂₅H₃₃P
Molecular weight	364.5 g/mol
Exact mass	364.232
InChIKey	GPVWUKXZFDHGMZ-UHFFFAOYSA-N
SMILES	CC1=CC=CC=C1C2=CC=CC=C2P(C3CCCCC3)C4CCCCC4
PubChem CID	2734938

Physical properties
Physical form	Solid
LogP (XLogP3)	7.1
H-bond donors / acceptors	0 / 0
TPSA	0 Å²
Synonyms	Dicyclohexyl(2'-methyl-[1,1'-biphenyl]-2-yl)phosphine, dicyclohexyl(2'-methyl-[1,1'-biphenyl]-2-yl)phosphane, dicyclohexyl-[2-(o-tolyl)phenyl]phosphane, 2-Dicyclohexylphosphino-2 inverted exclamation mark -methylbiphenyl, Dicyclohexyl(2'-methyl-2-biphenylyl)phosphine, Dicyclohexyl-(2'-methyl-biphenyl-2-yl)-phosphane, Dicyclohexyl(2'-methyl[1,1'-biphenyl]-2-yl)phosphane, 2-Dicyclohexylphosphino-2 inverted exclamation marka-methylbiphenyl

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P272, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P333 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-(Dicyclohexylphosphino)-2'-methylbiphenyl?

The CAS Registry Number of 2-(Dicyclohexylphosphino)-2'-methylbiphenyl is 251320-86-2. It is also known as Dicyclohexyl(2'-methyl-[1,1'-biphenyl]-2-yl)phosphine, dicyclohexyl(2'-methyl-[1,1'-biphenyl]-2-yl)phosphane, dicyclohexyl-[2-(o-tolyl)phenyl]phosphane.

What is the molecular formula and molecular weight of 2-(Dicyclohexylphosphino)-2'-methylbiphenyl?

2-(Dicyclohexylphosphino)-2'-methylbiphenyl has the molecular formula C25H33P and a molecular weight of 364.5 g/mol. Its IUPAC name is dicyclohexyl-[2-(2-methylphenyl)phenyl]phosphane.

What is 2-(Dicyclohexylphosphino)-2'-methylbiphenyl used for?

2-(Dicyclohexylphosphino)-2'-methylbiphenyl is supplied as a characterised reference material related to Loperamide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-(Dicyclohexylphosphino)-2'-methylbiphenyl can I order?

We supply 2-(Dicyclohexylphosphino)-2'-methylbiphenyl, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-(Dicyclohexylphosphino)-2'-methylbiphenyl?

Yes. Every lot of 2-(Dicyclohexylphosphino)-2'-methylbiphenyl is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-(Dicyclohexylphosphino)-2'-methylbiphenyl be shipped internationally?

Yes. 2-(Dicyclohexylphosphino)-2'-methylbiphenyl is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.