2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid 178306-51-9

Name: 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid
Brand: Vaqora Chemicals
SKU: VQ-023383

About 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid

2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid is a metabolite or degradation product of Ambrisentan carrying the CAS registry number 178306-51-9. The compound has the formula C16H16O4, corresponding to a molecular weight of 272.29 g/mol. Alternative names: 2-Hydroxy-3-methoxy-3,3-diphenylpropionic a.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Ambrisentan, as well as in QC testing and ANDA/DMF documentation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ambrisentan

View every impurity, metabolite and intermediate we list for Ambrisentan.

Ambrisentan impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid
Catalogue No.	VQ-023383
CAS Number	178306-51-9
IUPAC name	2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
Molecular formula	C₁₆H₁₆O₄
Molecular weight	272.29 g/mol
Exact mass	272.1049
Grade	Reference Standard
HSN code	38229090
InChIKey	RQJWOLFMWKZKCJ-UHFFFAOYSA-N
SMILES	COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(C(=O)O)O
PubChem CID	9881947

Physical properties
Physical form	Solid
LogP (XLogP3)	2
H-bond donors / acceptors	2 / 4
TPSA	66.8 Å²
Synonyms	2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid, Benzenepropanoic acid, alpha-hydroxy-beta-methoxy-beta-phenyl-, Benzenepropanoic acid, .alpha.-hydroxy-.beta.-methoxy-.beta.-phenyl-, 2-Hydroxy-3-methoxy -3,3-diphenyl propionic acid, 2-Hydroxy-3-methoxy-3,3-diphenylpropionic a, 2-hydroxy-3-methoxy-3,3-diphenyl propionic acid, Benzenepropanoic acid,, A-hydroxy-, A-methoxy-, A-phenyl-, racemic 2-hydroxy-3-methoxy-3,3-diphenyl propionic acid

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid?

The CAS Registry Number of 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid is 178306-51-9. It is also known as 2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid, Benzenepropanoic acid, alpha-hydroxy-beta-methoxy-beta-phenyl-, Benzenepropanoic acid, .alpha.-hydroxy-.beta.-methoxy-.beta.-phenyl-.

What is the molecular formula and molecular weight of 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid?

2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid has the molecular formula C16H16O4 and a molecular weight of 272.29 g/mol. Its IUPAC name is 2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid.

What is 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid used for?

2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid is supplied as a characterised reference material related to Ambrisentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid can I order?

We supply 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid?

Yes. Every lot of 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid be shipped internationally?

Yes. 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.