(2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-prop… 123367-26-0

Name: (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one
Brand: Vaqora Chemicals
SKU: VQ-012741

About (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one

(2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one (CAS 123367-26-0) is a process intermediate or related compound of Nilotinib offered by Vaqora Chemicals. The compound has the formula C10H12N2O, corresponding to a molecular weight of 176.21 g/mol. Its systematic (IUPAC) name is (E)-3-(dimethylamino)-1-pyridin-3-ylprop-2-en-1-one. Common synonyms include 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one and 2-(Dimethylamino)vinyl 3-Pyridyl Ketone.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 8 hazard statements. Review the Safety Data Sheet before use.

Process chemists and analysts use it when developing synthetic routes to Nilotinib, tracking process-related impurities and validating analytical methods. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. Stock is available for quick dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Nilotinib

View every impurity, metabolite and intermediate we list for Nilotinib.

Nilotinib impurities

Specifications & identifiers

Chemical identifiers
Product name	(2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one
Catalogue No.	VQ-012741
CAS Number	123367-26-0
IUPAC name	(E)-3-(dimethylamino)-1-pyridin-3-ylprop-2-en-1-one
Molecular formula	C₁₀H₁₂N₂O
Molecular weight	176.21 g/mol
Exact mass	176.095
Grade	Reference Standard
HSN code	2933
InChIKey	MZLRFUCMBQWLNV-FNORWQNLSA-N
SMILES	CN(C)/C=C/C(=O)C1=CN=CC=C1
PubChem CID	5369165

Physical properties
Physical form	Solid
LogP (XLogP3)	0.8
H-bond donors / acceptors	0 / 3
TPSA	33.2 Å²
Synonyms	(E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one, (2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one, (2E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one, 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one, 3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one, 2-propen-1-one, 3-(dimethylamino)-1-(3-pyridinyl)-, (2E)-, 2-(Dimethylamino)vinyl 3-Pyridyl Ketone, 3-dimethylamino-1-pyridin-3-yl-propenone, (E)-3-Dimethylamino-1-(pyridin-3-yl)prop-2-en-1-one, 3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one, (Z)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects

Precautionary statements: P260, P261, P264, P264 + P265, P270, P271, P272, P273, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P333 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one?

The CAS Registry Number of (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one is 123367-26-0. It is also known as (E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one, (2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one, (2E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one.

What is the molecular formula and molecular weight of (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one?

(2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one has the molecular formula C10H12N2O and a molecular weight of 176.21 g/mol. Its IUPAC name is (E)-3-(dimethylamino)-1-pyridin-3-ylprop-2-en-1-one.

What is (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one used for?

(2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one is supplied as a characterised reference material related to Nilotinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one can I order?

We supply (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one?

Yes. Every lot of (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one be shipped internationally?

Yes. (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.