(2R)-3-Acetylthio-2-methylpropionyl Chloride 74345-73-6

Name: (2R)-3-Acetylthio-2-methylpropionyl Chloride
Brand: Vaqora Chemicals
SKU: VQ-034960

About (2R)-3-Acetylthio-2-methylpropionyl Chloride

(2R)-3-Acetylthio-2-methylpropionyl Chloride is an impurity of Captopril carrying the CAS registry number 74345-73-6. Formula C6H9ClO2S, molecular weight 180.65 g/mol. The IUPAC name is S-[(2R)-3-chloro-2-methyl-3-oxopropyl] ethanethioate. Alternative names: (R)-3-(Acetylthio)isobutyryl Chloride and (R)-3-acetylthio-2-methylpropanoyl chloride.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Captopril, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, (2R)-3-Acetylthio-2-methylpropionyl Chloride is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Captopril

View every impurity, metabolite and intermediate we list for Captopril.

Captopril impurities

Specifications & identifiers

Chemical identifiers
Product name	(2R)-3-Acetylthio-2-methylpropionyl Chloride
Catalogue No.	VQ-034960
CAS Number	74345-73-6
IUPAC name	S-[(2R)-3-chloro-2-methyl-3-oxopropyl] ethanethioate
Molecular formula	C₆H₉ClO₂S
Molecular weight	180.65 g/mol
Exact mass	180.0012
Grade	Reference Standard
HSN code	38229090
InChIKey	LUDPWTHDXSOXDX-SCSAIBSYSA-N
SMILES	C[C@H](CSC(=O)C)C(=O)Cl
PubChem CID	11830043

Physical properties
Physical form	Solid
LogP (XLogP3)	1.7
H-bond donors / acceptors	0 / 3
TPSA	59.4 Å²

Safety & hazard information (GHS)

Corrosive

Signal word: Danger

Hazard statements

H290May be corrosive to metals
H314Causes severe skin burns and eye damage
H318Causes serious eye damage

Precautionary statements: P234, P260, P264, P264 + P265, P280, P301 + P330 + P331, P302 + P361 + P354, P304 + P340, P305 + P354 + P338, P316, P317, P321, P363, P390, P405, P406, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (2R)-3-Acetylthio-2-methylpropionyl Chloride?

The CAS Registry Number of (2R)-3-Acetylthio-2-methylpropionyl Chloride is 74345-73-6. It is also known as (R)-3-(Acetylthio)isobutyryl Chloride, (R)-S-(3-chloro-2-methyl-3-oxopropyl) ethanethioate, (R)-3-acetylthio-2-methylpropanoyl chloride.

What is the molecular formula and molecular weight of (2R)-3-Acetylthio-2-methylpropionyl Chloride?

(2R)-3-Acetylthio-2-methylpropionyl Chloride has the molecular formula C6H9ClO2S and a molecular weight of 180.65 g/mol. Its IUPAC name is S-[(2R)-3-chloro-2-methyl-3-oxopropyl] ethanethioate.

What is (2R)-3-Acetylthio-2-methylpropionyl Chloride used for?

(2R)-3-Acetylthio-2-methylpropionyl Chloride is supplied as a characterised reference material related to Captopril. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (2R)-3-Acetylthio-2-methylpropionyl Chloride can I order?

We supply (2R)-3-Acetylthio-2-methylpropionyl Chloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (2R)-3-Acetylthio-2-methylpropionyl Chloride?

Yes. Every lot of (2R)-3-Acetylthio-2-methylpropionyl Chloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (2R)-3-Acetylthio-2-methylpropionyl Chloride be shipped internationally?

Yes. (2R)-3-Acetylthio-2-methylpropionyl Chloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.