3-Hydroxy-1(3H)-isobenzofuranone

Name: 3-Hydroxy-1(3H)-isobenzofuranone
Brand: Vaqora Chemicals
SKU: VQ-013023

About 3-Hydroxy-1(3H)-isobenzofuranone

3-Hydroxy-1(3H)-isobenzofuranone (CAS 16859-59-9) is a process intermediate or related compound of Olaparib offered by Vaqora Chemicals. Formula C8H6O3, molecular weight 150.13 g/mol. Systematically, it is named 3-hydroxy-3H-2-benzofuran-1-one. Alternative names: 3-Hydroxyphthalide and (±)-3-Hydroxy-1(3H)-isobenzofuranone.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is a process intermediate or related compound in the synthesis of Olaparib, useful for route development, impurity fate-and-purge studies and analytical method development. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Olaparib

View every impurity, metabolite and intermediate we list for Olaparib.

Olaparib impurities

Specifications & identifiers

Chemical identifiers
Product name	3-Hydroxy-1(3H)-isobenzofuranone
Catalogue No.	VQ-013023
CAS Number	16859-59-9
IUPAC name	3-hydroxy-3H-2-benzofuran-1-one
Molecular formula	C₈H₆O₃
Molecular weight	150.13 g/mol
Exact mass	150.0317
Grade	Reference Standard
InChIKey	JKNKNWJNCOJPLI-UHFFFAOYSA-N
SMILES	C1=CC=C2C(=C1)C(OC2=O)O
PubChem CID	3804259

Physical properties
Physical form	Solid
LogP (XLogP3)	0.6
H-bond donors / acceptors	1 / 3
TPSA	46.5 Å²
Synonyms	3-Hydroxyphthalide, (±)-3-Hydroxy-1(3H)-isobenzofuranone, (±)-3-Hydroxyphthalide, 3-Hydroxy-1,3-dihydro-2-benzofuran-1-one, 3-Hydroxybenzo[c]furan-1(3H)-one, 3-hydroxyisobenzofuran-1(3H)-one, o-Phthalaldehydic acid, hydroxyphthalide, 3-hydroxy-2-benzofuran-1(3H)-one, 3-hydroxy-3H-isobenzofuran-1-one, 1(3H)-isobenzofuranone, 3-hydroxy-, hydroxyl phthalide

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-Hydroxy-1(3H)-isobenzofuranone?

The CAS Registry Number of 3-Hydroxy-1(3H)-isobenzofuranone is 16859-59-9. It is also known as 3-Hydroxyphthalide, (±)-3-Hydroxy-1(3H)-isobenzofuranone, (±)-3-Hydroxyphthalide.

What is the molecular formula and molecular weight of 3-Hydroxy-1(3H)-isobenzofuranone?

3-Hydroxy-1(3H)-isobenzofuranone has the molecular formula C8H6O3 and a molecular weight of 150.13 g/mol. Its IUPAC name is 3-hydroxy-3H-2-benzofuran-1-one.

What is 3-Hydroxy-1(3H)-isobenzofuranone used for?

3-Hydroxy-1(3H)-isobenzofuranone is supplied as a characterised reference material related to Olaparib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-Hydroxy-1(3H)-isobenzofuranone can I order?

We supply 3-Hydroxy-1(3H)-isobenzofuranone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-Hydroxy-1(3H)-isobenzofuranone?

Yes. Every lot of 3-Hydroxy-1(3H)-isobenzofuranone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-Hydroxy-1(3H)-isobenzofuranone be shipped internationally?

Yes. 3-Hydroxy-1(3H)-isobenzofuranone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.