3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro… 1668-86-6

Name: 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one
Brand: Vaqora Chemicals
SKU: VQ-048501

About 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one

Listed under CAS 1668-86-6, 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one is a process intermediate or related compound of Galantamine available from Vaqora Chemicals. With the molecular formula C17H19NO3, it has a molar mass of 285.34 g/mol. Its systematic (IUPAC) name is (1S,12S)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-one. Common synonyms include Galanthaminone and Narwedine.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

It is a process intermediate or related compound in the synthesis of Galantamine, useful for route development, impurity fate-and-purge studies and analytical method development. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Galantamine

View every impurity, metabolite and intermediate we list for Galantamine.

Galantamine impurities

Specifications & identifiers

Chemical identifiers
Product name	3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one
Catalogue No.	VQ-048501
CAS Number	1668-86-6
IUPAC name	(1S,12S)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-one
Molecular formula	C₁₇H₁₉NO₃
Molecular weight	285.34 g/mol
Exact mass	285.1365
HSN code	2933
InChIKey	QENVUHCAYXAROT-YOEHRIQHSA-N
SMILES	CN1CC[C@@]23C=CC(=O)C[C@@H]2OC4=C(C=CC(=C34)C1)OC
PubChem CID	10356588

Physical properties
Physical form	Solid
LogP (XLogP3)	1.7
H-bond donors / acceptors	0 / 4
TPSA	38.8 Å²
Synonyms	Galanthaminone, Narwedine, (-)-Narwedine, Galanthamine, 3-deoxy-3-oxo-, (+/-)-Narwedine, Narwedine, (+/-)-, Narwedin, 3-Deoxy-3-oxo-galanthamine, DL-Narwedine, rel-(4aR,8aR)-3-Methoxy-11-methyl-4a,5,9,10, ( inverted exclamation markA)-Narwedine ( inverted exclamation markA-Galanthaminone), (4aS8aS)-4a59101112-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a32-ef][2]benzazepin-6-one

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H331Toxic if inhaled

Precautionary statements: P261, P264, P270, P271, P272, P280, P301 + P316, P302 + P352, P304 + P340, P316, P321, P330, P332 + P317, P333 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one?

The CAS Registry Number of 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one is 1668-86-6. It is also known as Galanthaminone, Narwedine, (-)-Narwedine.

What is the molecular formula and molecular weight of 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one?

3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one has the molecular formula C17H19NO3 and a molecular weight of 285.34 g/mol. Its IUPAC name is (1S,12S)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-one.

What is 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one used for?

3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one is supplied as a characterised reference material related to Galantamine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one can I order?

We supply 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one?

Yes. Every lot of 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one be shipped internationally?

Yes. 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.