3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole 219986-64-8

Name: 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole
Brand: Vaqora Chemicals
SKU: VQ-021122

About 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole

Vaqora Chemicals supplies 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole, an impurity of Celecoxib registered under CAS number 219986-64-8. The compound has the formula C11H9F3N2, corresponding to a molecular weight of 226.2 g/mol. The IUPAC name is 3-(4-methylphenyl)-5-(trifluoromethyl)-1H-pyrazole. It is also known as Celecoxib N-des(benzenesulfonamide) or 5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazole.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Celecoxib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Celecoxib

View every impurity, metabolite and intermediate we list for Celecoxib.

Celecoxib impurities

Specifications & identifiers

Chemical identifiers
Product name	3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole
Catalogue No.	VQ-021122
CAS Number	219986-64-8
IUPAC name	3-(4-methylphenyl)-5-(trifluoromethyl)-1H-pyrazole
Molecular formula	C₁₁H₉F₃N₂
Molecular weight	226.2 g/mol
Exact mass	226.0718
Grade	Reference Standard
HSN code	38229090
InChIKey	NQEFIPVOJGJVRG-UHFFFAOYSA-N
SMILES	CC1=CC=C(C=C1)C2=NNC(=C2)C(F)(F)F
PubChem CID	4166967

Physical properties
Physical form	Solid
LogP (XLogP3)	3.2
H-bond donors / acceptors	1 / 4
TPSA	28.7 Å²
Synonyms	Celecoxib N-des(benzenesulfonamide), 5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazole, 1H-Pyrazole, 5-(4-methylphenyl)-3-(trifluoromethyl)-, 5-(4-methylphenyl)-3-trifluoromethyl-1h-pyrazole, 3-(4-methylphenyl)-5-(trifluoromethyl)pyrazole, 5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazole, 3-(Trifluoromethyl)-5-p-tolyl-1H-pyrazole, 3-trifluoromethyl-5-(p-tolyl)-1h-pyrazole, Celecoxib-010-1, 1H-Pyrazole, 3-(4-methylphenyl)-5-(trifluoromethyl)-, 3-p-tolyl-5-(trifluormethyl)-1H-pyrazole, 5-(4-Methylphenyl)-3-(trifluoromethyl)py

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole?

The CAS Registry Number of 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole is 219986-64-8. It is also known as Celecoxib N-des(benzenesulfonamide), 5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazole, 1H-Pyrazole, 5-(4-methylphenyl)-3-(trifluoromethyl)-.

What is the molecular formula and molecular weight of 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole?

3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole has the molecular formula C11H9F3N2 and a molecular weight of 226.2 g/mol. Its IUPAC name is 3-(4-methylphenyl)-5-(trifluoromethyl)-1H-pyrazole.

What is 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole used for?

3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole is supplied as a characterised reference material related to Celecoxib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole can I order?

We supply 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole?

Yes. Every lot of 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole be shipped internationally?

Yes. 3-(p-Tolyl)-5-(trifluoromethyl)-1H-pyrazole is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.