4-Amino-3-(triflouromethyl) Benzonitrile

Name: 4-Amino-3-(triflouromethyl) Benzonitrile
Brand: Vaqora Chemicals
SKU: VQ-021826

About 4-Amino-3-(triflouromethyl) Benzonitrile

Listed under CAS 327-74-2, 4-Amino-3-(triflouromethyl) Benzonitrile is an impurity of Bicalutamide available from Vaqora Chemicals. The compound has the formula C8H5F3N2, corresponding to a molecular weight of 186.13 g/mol. Its systematic (IUPAC) name is 4-amino-3-(trifluoromethyl)benzonitrile. Alternative names: 2-Amino-5-cyanobenzotrifluoride and 2-trifluoromethyl-4-cyanoaniline.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Bicalutamide to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Bicalutamide

View every impurity, metabolite and intermediate we list for Bicalutamide.

Bicalutamide impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Amino-3-(triflouromethyl) Benzonitrile
Catalogue No.	VQ-021826
CAS Number	327-74-2
IUPAC name	4-amino-3-(trifluoromethyl)benzonitrile
Molecular formula	C₈H₅F₃N₂
Molecular weight	186.13 g/mol
Exact mass	186.0405
Grade	Reference Standard
HSN code	38229090
InChIKey	MWLZJOBGDXBMBP-UHFFFAOYSA-N
SMILES	C1=CC(=C(C=C1C#N)C(F)(F)F)N
PubChem CID	2779488

Physical properties
Physical form	Solid
LogP (XLogP3)	1.8
H-bond donors / acceptors	1 / 5
TPSA	49.8 Å²
Synonyms	2-Amino-5-cyanobenzotrifluoride, 2-trifluoromethyl-4-cyanoaniline, 4-amino-3-(trifluoromethyl)benzenecarbonitrile, 4-Cyano-2-(trifluoromethyl)aniline, Benzonitrile, 4-amino-3-(trifluoromethyl)-, 4-amino-3-trifluoromethyl-benzonitrile, 4-amino-3-(trifluoromethyl)benzoni-trile, 4-Amino-3-trifluoromethylbenzonitrile 2-Amino-5-cyanobenzotrifluoride

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H301+H311+H331Toxic if swallowed, in contact with skin or if inhaled
H301Toxic if swallowed
H302Harmful if swallowed
H311Toxic in contact with skin
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P262, P264, P264 + P265, P270, P271, P280, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P317, P319, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Amino-3-(triflouromethyl) Benzonitrile?

The CAS Registry Number of 4-Amino-3-(triflouromethyl) Benzonitrile is 327-74-2. It is also known as 2-Amino-5-cyanobenzotrifluoride, 2-trifluoromethyl-4-cyanoaniline, 4-amino-3-(trifluoromethyl)benzenecarbonitrile.

What is the molecular formula and molecular weight of 4-Amino-3-(triflouromethyl) Benzonitrile?

4-Amino-3-(triflouromethyl) Benzonitrile has the molecular formula C8H5F3N2 and a molecular weight of 186.13 g/mol. Its IUPAC name is 4-amino-3-(trifluoromethyl)benzonitrile.

What is 4-Amino-3-(triflouromethyl) Benzonitrile used for?

4-Amino-3-(triflouromethyl) Benzonitrile is supplied as a characterised reference material related to Bicalutamide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Amino-3-(triflouromethyl) Benzonitrile can I order?

We supply 4-Amino-3-(triflouromethyl) Benzonitrile in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Amino-3-(triflouromethyl) Benzonitrile?

Yes. Every lot of 4-Amino-3-(triflouromethyl) Benzonitrile is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Amino-3-(triflouromethyl) Benzonitrile be shipped internationally?

Yes. 4-Amino-3-(triflouromethyl) Benzonitrile is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.