4-Hydroxyestradiol

Name: 4-Hydroxyestradiol
Brand: Vaqora Chemicals
SKU: VQ-048278

About 4-Hydroxyestradiol

Vaqora Chemicals supplies 4-Hydroxyestradiol, a metabolite or degradation product of Estriol registered under CAS number 5976-61-4. Its molecular formula is C18H24O3 and its molecular weight is 288.4 g/mol. Its systematic (IUPAC) name is (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol. Alternative names: 4-OH-Estradiol and 4-Hydroxyestradiol-17beta.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Estriol, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer 4-Hydroxyestradiol in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Estriol

View every impurity, metabolite and intermediate we list for Estriol.

Estriol impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Hydroxyestradiol
Catalogue No.	VQ-048278
CAS Number	5976-61-4
IUPAC name	(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol
Molecular formula	C₁₈H₂₄O₃
Molecular weight	288.4 g/mol
Exact mass	288.1725
Grade	Reference Standard
HSN code	38229090
InChIKey	QOZFCKXEVSGWGS-ZHIYBZGJSA-N
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4O)O
PubChem CID	5282360

Physical properties
Physical form	Solid
LogP (XLogP3)	3.7
H-bond donors / acceptors	3 / 3
TPSA	60.7 Å²
Synonyms	4-OH-Estradiol, 4-Hydroxyestradiol-17beta, 4-hydroxyestradiol-17 beta, 3,4,17beta-estriol, 4OHE2, 4-Hydroxy-17-beta-estradiol, estra-1,3,5(10)-triene-2,4,17beta-triol, 3,4,17beta-trihydroxy-1,3,5[10]-estratriene, 1,3,5(10)-Estratriene-3,4,17beta-triol, estra-1,3,5(10)-triene-3,14,17beta-triol, 3,4,17beta-Trihydroxy-1,3,5(10)-Estratriene, 4-OHE2

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Hydroxyestradiol?

The CAS Registry Number of 4-Hydroxyestradiol is 5976-61-4. It is also known as 4-OH-Estradiol, 4-Hydroxyestradiol-17beta, 4-hydroxyestradiol-17 beta.

What is the molecular formula and molecular weight of 4-Hydroxyestradiol?

4-Hydroxyestradiol has the molecular formula C18H24O3 and a molecular weight of 288.4 g/mol. Its IUPAC name is (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol.

What is 4-Hydroxyestradiol used for?

4-Hydroxyestradiol is supplied as a characterised reference material related to Estriol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Hydroxyestradiol can I order?

We supply 4-Hydroxyestradiol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Hydroxyestradiol?

Yes. Every lot of 4-Hydroxyestradiol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Hydroxyestradiol be shipped internationally?

Yes. 4-Hydroxyestradiol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.