4-(Trifluoromethyl)Anisole

Name: 4-(Trifluoromethyl)Anisole
Brand: Vaqora Chemicals
SKU: VQ-051100

About 4-(Trifluoromethyl)Anisole

Listed under CAS 402-52-8, 4-(Trifluoromethyl)Anisole is a process intermediate or related compound of Allopurinol available from Vaqora Chemicals. With the molecular formula C8H7F3O, it has a molar mass of 176.14 g/mol. The IUPAC name is 1-methoxy-4-(trifluoromethyl)benzene. Alternative names: Benzene, 1-methoxy-4-(trifluoromethyl)- and 1-methoxy-4-trifluoromethyl-benzene.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is a process intermediate or related compound in the synthesis of Allopurinol, useful for route development, impurity fate-and-purge studies and analytical method development. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer 4-(Trifluoromethyl)Anisole in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Allopurinol

View every impurity, metabolite and intermediate we list for Allopurinol.

Allopurinol impurities

Specifications & identifiers

Chemical identifiers
Product name	4-(Trifluoromethyl)Anisole
Catalogue No.	VQ-051100
CAS Number	402-52-8
IUPAC name	1-methoxy-4-(trifluoromethyl)benzene
Molecular formula	C₈H₇F₃O
Molecular weight	176.14 g/mol
Exact mass	176.0449
InChIKey	CFIPQRIPCRRISV-UHFFFAOYSA-N
SMILES	COC1=CC=C(C=C1)C(F)(F)F
PubChem CID	600604

Physical properties
Physical form	Solid
LogP (XLogP3)	3.2
H-bond donors / acceptors	0 / 4
TPSA	9.2 Å²
Synonyms	Benzene, 1-methoxy-4-(trifluoromethyl)-, 1-methoxy-4-trifluoromethyl-benzene, p-trifluoromethylanisole, 4-trifluoromethyl-anisol, 4-methoxy-1-(trifluoromethyl)benzene, Methyl 4-(trifluoromethyl)phenyl ether #

Safety & hazard information (GHS)

Flammable

Harmful / irritant

Signal word: Danger

Hazard statements

H225Highly flammable liquid and vapor
H226Flammable liquid and vapor
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P210, P233, P240, P241, P242, P243, P261, P264, P264 + P265, P271, P280, P302 + P352, P303 + P361 + P353, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P370 + P378, P403 + P233, P403 + P235, P405

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-(Trifluoromethyl)Anisole?

The CAS Registry Number of 4-(Trifluoromethyl)Anisole is 402-52-8. It is also known as Benzene, 1-methoxy-4-(trifluoromethyl)-, 1-methoxy-4-trifluoromethyl-benzene, p-trifluoromethylanisole.

What is the molecular formula and molecular weight of 4-(Trifluoromethyl)Anisole?

4-(Trifluoromethyl)Anisole has the molecular formula C8H7F3O and a molecular weight of 176.14 g/mol. Its IUPAC name is 1-methoxy-4-(trifluoromethyl)benzene.

What is 4-(Trifluoromethyl)Anisole used for?

4-(Trifluoromethyl)Anisole is supplied as a characterised reference material related to Allopurinol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-(Trifluoromethyl)Anisole can I order?

We supply 4-(Trifluoromethyl)Anisole, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-(Trifluoromethyl)Anisole?

Yes. Every lot of 4-(Trifluoromethyl)Anisole is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-(Trifluoromethyl)Anisole be shipped internationally?

Yes. 4-(Trifluoromethyl)Anisole is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.