6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dio… 887581-47-7

Name: 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione
Brand: Vaqora Chemicals
SKU: VQ-038261

About 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione

6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione (CAS 887581-47-7) is an impurity of Mavacamten offered by Vaqora Chemicals. Formula C7H9ClN2O2, molecular weight 188.61 g/mol. Systematically, it is named 6-chloro-3-propan-2-yl-1H-pyrimidine-2,4-dione. It is also known as 3-isopropyl-6-chlorouracil or 6-chloro-3-isopropyl-1H-pyrimidine-2,4-dione.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Mavacamten to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Mavacamten

View every impurity, metabolite and intermediate we list for Mavacamten.

Mavacamten impurities

Specifications & identifiers

Chemical identifiers
Product name	6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione
Catalogue No.	VQ-038261
CAS Number	887581-47-7
IUPAC name	6-chloro-3-propan-2-yl-1H-pyrimidine-2,4-dione
Molecular formula	C₇H₉ClN₂O₂
Molecular weight	188.61 g/mol
Exact mass	188.0353
Grade	Reference Standard
HSN code	38229090
InChIKey	KGNSZFNQYGWUGX-UHFFFAOYSA-N
SMILES	CC(C)N1C(=O)C=C(NC1=O)Cl
PubChem CID	820107

Physical properties
Physical form	Solid
LogP (XLogP3)	0.8
H-bond donors / acceptors	1 / 2
TPSA	49.4 Å²
Synonyms	6-chloro-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione, 2,4(1H,3H)-pyrimidinedione, 6-chloro-3-(1-methylethyl)-, 3-isopropyl-6-chlorouracil, 6-chloro-3-isopropyl-1H-pyrimidine-2,4-dione, 6-Chloro-3-isopropyl-2,4(1H,3H)-pyrimidinedione, 6-Chloro-3-(1-methylethyl)-2,4(1H,3H)-pyrimidinedione, 6-chloro-3-(methylethyl)-1,3-dihydropyrimidine-2,4-dione

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione?

The CAS Registry Number of 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione is 887581-47-7. It is also known as 6-chloro-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione, 2,4(1H,3H)-pyrimidinedione, 6-chloro-3-(1-methylethyl)-, 3-isopropyl-6-chlorouracil.

What is the molecular formula and molecular weight of 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione?

6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione has the molecular formula C7H9ClN2O2 and a molecular weight of 188.61 g/mol. Its IUPAC name is 6-chloro-3-propan-2-yl-1H-pyrimidine-2,4-dione.

What is 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione used for?

6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione is supplied as a characterised reference material related to Mavacamten. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione can I order?

We supply 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione?

Yes. Every lot of 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione be shipped internationally?

Yes. 6-Chloro-3-isopropylpyrimidine-2,4(1H,3H)-dione is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.