6-Fluorochromane-2-carboxylic acid

Name: 6-Fluorochromane-2-carboxylic acid
Brand: Vaqora Chemicals
SKU: VQ-032084

About 6-Fluorochromane-2-carboxylic acid

6-Fluorochromane-2-carboxylic acid (CAS 99199-60-7) is an impurity of Nebivolol offered by Vaqora Chemicals. The compound has the formula C10H9FO3, corresponding to a molecular weight of 196.17 g/mol. Systematically, it is named 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid. Alternative names: Fluorochroman-2-carboxylic acid and 6-fluoroisochromane-1-carboxylic acid.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Nebivolol, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Nebivolol

View every impurity, metabolite and intermediate we list for Nebivolol.

Nebivolol impurities

Specifications & identifiers

Chemical identifiers
Product name	6-Fluorochromane-2-carboxylic acid
Catalogue No.	VQ-032084
CAS Number	99199-60-7
IUPAC name	6-fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid
Molecular formula	C₁₀H₉FO₃
Molecular weight	196.17 g/mol
Exact mass	196.0536
Grade	Reference Standard
HSN code	38229090
InChIKey	ZNJANLXCXMVFFI-UHFFFAOYSA-N
SMILES	C1CC2=C(C=CC(=C2)F)OC1C(=O)O
PubChem CID	15382843

Physical properties
Physical form	Solid
LogP (XLogP3)	2
H-bond donors / acceptors	1 / 4
TPSA	46.5 Å²
Synonyms	6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid, 6-Fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid, rac-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic Acid, 6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-CarboxylicAcid, Fluorochroman-2-carboxylic acid, 6-fluoroisochromane-1-carboxylic acid, (2S)-6-Fluoro-2-chromanecarboxylic acid, 6-fluoro-3,4-dihydro-2h-chroman-2-carboxylic acid, 6-fluoro-3,4-dihydro-2H-chromen-2-carboxylic acid, 6-fluoranyl-3,4-dihydro-1H-isochromene-1-carboxylic acid, (S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2alpha-carboxylic acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 6-Fluorochromane-2-carboxylic acid?

The CAS Registry Number of 6-Fluorochromane-2-carboxylic acid is 99199-60-7. It is also known as 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid, 6-Fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid, rac-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic Acid.

What is the molecular formula and molecular weight of 6-Fluorochromane-2-carboxylic acid?

6-Fluorochromane-2-carboxylic acid has the molecular formula C10H9FO3 and a molecular weight of 196.17 g/mol. Its IUPAC name is 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid.

What is 6-Fluorochromane-2-carboxylic acid used for?

6-Fluorochromane-2-carboxylic acid is supplied as a characterised reference material related to Nebivolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 6-Fluorochromane-2-carboxylic acid can I order?

We supply 6-Fluorochromane-2-carboxylic acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 6-Fluorochromane-2-carboxylic acid?

Yes. Every lot of 6-Fluorochromane-2-carboxylic acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 6-Fluorochromane-2-carboxylic acid be shipped internationally?

Yes. 6-Fluorochromane-2-carboxylic acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.