8-Hydroxy Amoxapine

Name: 8-Hydroxy Amoxapine
Brand: Vaqora Chemicals
SKU: VQ-020795

About 8-Hydroxy Amoxapine

8-Hydroxy Amoxapine is a metabolite or degradation product of Amoxapine carrying the CAS registry number 61443-78-5. Its molecular formula is C17H16ClN3O2 and its molecular weight is 329.8 g/mol. Its systematic (IUPAC) name is 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepin-3-ol. Common synonyms include 8-hydroxy desmethyl Loxapine and 8-Hydroxyamoxapin.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Amoxapine, as well as in QC testing and ANDA/DMF documentation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 8-Hydroxy Amoxapine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Amoxapine

View every impurity, metabolite and intermediate we list for Amoxapine.

Amoxapine impurities

Specifications & identifiers

Chemical identifiers
Product name	8-Hydroxy Amoxapine
Catalogue No.	VQ-020795
CAS Number	61443-78-5
IUPAC name	8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepin-3-ol
Molecular formula	C₁₇H₁₆ClN₃O₂
Molecular weight	329.8 g/mol
Exact mass	329.0931
Grade	Reference Standard
HSN code	38229090
InChIKey	QDWNOKXUZTYVGO-UHFFFAOYSA-N
SMILES	C1CN(CCN1)C2=NC3=C(C=CC(=C3)O)OC4=C2C=C(C=C4)Cl
PubChem CID	43656

Physical properties
Physical form	Solid
LogP (XLogP3)	2.2
H-bond donors / acceptors	2 / 4
TPSA	57.1 Å²
Synonyms	8-hydroxy desmethyl Loxapine, Dibenz(b,f)(1,4)oxazepin-8-ol, 2-chloro-11-(1-piperazinyl)-, 8-Hydroxyamoxapin, 8-Hydroxynorloxapine, 2-Chloro-11-(1-piperazinyl)-dibenz[b,f][1,4]oxazepin-8-ol, 8-chloro-6-piperazin-1-yl-benzo[b][1,4]benzoxazepin-3-ol, 2-Chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepin-8-ol, 2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepin-8-ol #

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P319, P321, P330, P332 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 8-Hydroxy Amoxapine?

The CAS Registry Number of 8-Hydroxy Amoxapine is 61443-78-5. It is also known as 8-hydroxy desmethyl Loxapine, Dibenz(b,f)(1,4)oxazepin-8-ol, 2-chloro-11-(1-piperazinyl)-, 8-Hydroxyamoxapin.

What is the molecular formula and molecular weight of 8-Hydroxy Amoxapine?

8-Hydroxy Amoxapine has the molecular formula C17H16ClN3O2 and a molecular weight of 329.8 g/mol. Its IUPAC name is 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepin-3-ol.

What is 8-Hydroxy Amoxapine used for?

8-Hydroxy Amoxapine is supplied as a characterised reference material related to Amoxapine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 8-Hydroxy Amoxapine can I order?

We supply 8-Hydroxy Amoxapine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 8-Hydroxy Amoxapine?

Yes. Every lot of 8-Hydroxy Amoxapine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 8-Hydroxy Amoxapine be shipped internationally?

Yes. 8-Hydroxy Amoxapine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.