Adagrasib

Name: Adagrasib
Brand: Vaqora Chemicals
SKU: VQ-007302

About Adagrasib

Adagrasib is a high-purity reference standard of Adagrasib carrying the CAS registry number 2326521-71-3. The compound has the formula C32H35ClFN7O2, corresponding to a molecular weight of 604.1 g/mol. Alternative names: MRTX 849 and MRTX-849.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a reference sample of Adagrasib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Adagrasib is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Adagrasib

View every impurity, metabolite and intermediate we list for Adagrasib.

Adagrasib impurities

Specifications & identifiers

Chemical identifiers
Product name	Adagrasib
Catalogue No.	VQ-007302
CAS Number	2326521-71-3
IUPAC name	2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile
Molecular formula	C₃₂H₃₅ClFN₇O₂
Molecular weight	604.1 g/mol
Exact mass	603.2525
Grade	Reference Standard
HSN code	38229090
InChIKey	PEMUGDMSUDYLHU-ZEQRLZLVSA-N
SMILES	CN1CCC[C@H]1COC2=NC3=C(CCN(C3)C4=CC=CC5=C4C(=CC=C5)Cl)C(=N2)N6CCN([C@H](C6)CC#N)C(=O)C(=C)F
PubChem CID	138611145

Physical properties
Physical form	Solid
LogP (XLogP3)	5
H-bond donors / acceptors	0 / 9
TPSA	88.8 Å²
Synonyms	MRTX 849, MRTX-849, Kras G12C inhibitor MRTX849, Adagrasib (MRTX849), Krazati (TN), Adagrasib (USAN/INN), MRTX849(Adagrasib)?, C32H35ClFN7O2, EX-A3258, compound 20 [PMID: 32250617]

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Adagrasib?

The CAS Registry Number of Adagrasib is 2326521-71-3. It is also known as MRTX 849, MRTX-849, Kras G12C inhibitor MRTX849.

What is the molecular formula and molecular weight of Adagrasib?

Adagrasib has the molecular formula C32H35ClFN7O2 and a molecular weight of 604.1 g/mol.

What is Adagrasib used for?

Adagrasib is supplied as a characterised reference material related to Adagrasib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Adagrasib can I order?

We supply Adagrasib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Adagrasib?

Yes. Every lot of Adagrasib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Adagrasib be shipped internationally?

Yes. Adagrasib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.