Axitinib Z-isomer

Name: Axitinib Z-isomer
Brand: Vaqora Chemicals
SKU: VQ-024454

About Axitinib Z-isomer

Axitinib Z-isomer is an impurity of Axitinib carrying the CAS registry number 885126-40-9. The compound has the formula C22H18N4OS, corresponding to a molecular weight of 386.5 g/mol. The IUPAC name is N-methyl-2-[[3-[(Z)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide. It is also known as Cis-axitinib or (Z)-Axitinib.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Axitinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Axitinib Z-isomer is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Axitinib

View every impurity, metabolite and intermediate we list for Axitinib.

Axitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Axitinib Z-isomer
Catalogue No.	VQ-024454
CAS Number	885126-40-9
IUPAC name	N-methyl-2-[[3-[(Z)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
Molecular formula	C₂₂H₁₈N₄OS
Molecular weight	386.5 g/mol
Exact mass	386.1201
Grade	Reference Standard
HSN code	38229090
InChIKey	RITAVMQDGBJQJZ-XFXZXTDPSA-N
SMILES	CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C\C4=CC=CC=N4
PubChem CID	23724859

Physical properties
Physical form	Solid
LogP (XLogP3)	4.2
H-bond donors / acceptors	2 / 4
TPSA	96 Å²
Synonyms	Cis-axitinib, (Z)-Axitinib, N-Methyl-2-((3-((Z)-2-(2-pyridinyl)vinyl)-1H-indazol-6-yl)sulfanyl)benzamide, N-Methyl-2-({3-[(Z)-2-(2-pyridinyl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide, (Z)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide, N-Methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide, Benzamide, N-methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-, N-methyl-2-[[3-[(Z)-2-(2-pyridyl)vinyl]-1H-indazol-6-yl]sulfanyl]benzamide

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P264, P270, P280, P301 + P317, P318, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Axitinib Z-isomer?

The CAS Registry Number of Axitinib Z-isomer is 885126-40-9. It is also known as Cis-axitinib, (Z)-Axitinib, N-Methyl-2-((3-((Z)-2-(2-pyridinyl)vinyl)-1H-indazol-6-yl)sulfanyl)benzamide.

What is the molecular formula and molecular weight of Axitinib Z-isomer?

Axitinib Z-isomer has the molecular formula C22H18N4OS and a molecular weight of 386.5 g/mol. Its IUPAC name is N-methyl-2-[[3-[(Z)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide.

What is Axitinib Z-isomer used for?

Axitinib Z-isomer is supplied as a characterised reference material related to Axitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Axitinib Z-isomer can I order?

We supply Axitinib Z-isomer in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Axitinib Z-isomer?

Yes. Every lot of Axitinib Z-isomer is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Axitinib Z-isomer be shipped internationally?

Yes. Axitinib Z-isomer is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.