Bendamustine Monohydroxy Impurity

Name: Bendamustine Monohydroxy Impurity
Brand: Vaqora Chemicals
SKU: VQ-004513

About Bendamustine Monohydroxy Impurity

Listed under CAS 109882-27-1, Bendamustine Monohydroxy Impurity is an impurity of Bendamustine available from Vaqora Chemicals. Its molecular formula is C16H22ClN3O3 and its molecular weight is 339.82 g/mol. Systematically, it is named 4-[5-[2-chloroethyl(2-hydroxyethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid. It is also known as Bendamustine Related Compound E (USP) or Hydroxy Bendamustine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Bendamustine, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Bendamustine Monohydroxy Impurity in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Bendamustine

View every impurity, metabolite and intermediate we list for Bendamustine.

Bendamustine impurities

Specifications & identifiers

Chemical identifiers
Product name	Bendamustine Monohydroxy Impurity
Catalogue No.	VQ-004513
CAS Number	109882-27-1
Other CAS	109882-26-0
IUPAC name	4-[5-[2-chloroethyl(2-hydroxyethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
Molecular formula	C₁₆H₂₂ClN₃O₃
Molecular weight	339.82 g/mol
Exact mass	339.135
Grade	Reference Standard
HSN code	38229090
InChIKey	PFTRYOMJJKBZKV-UHFFFAOYSA-N
SMILES	CN1C2=C(C=C(C=C2)N(CCO)CCCl)N=C1CCCC(=O)O
PubChem CID	23238076

Physical properties
Physical form	Solid
LogP (XLogP3)	1.6
H-bond donors / acceptors	2 / 5
TPSA	78.6 Å²
Synonyms	5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid, 4-{5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H -benzimidazol-2-yl}butanoic acid, Bendamustine Related Compound E (USP), Hydroxy Bendamustine, Bendamustine Impurity A, DES(2-chloroethyl)-(2-hydroxyethyl) bendamustine, 1H-Benzimidazole-2-butanoic acid, 5-((2-chloroethyl)(2-hydroxyethyl)amino)-1-methyl-, 4-(5-((2-Chloroethyl)(2-hydroxyethyl)amino)-1-methyl-1H-benzimidazol-2-yl)butanoic acid, 5-((2-Chloroethyl)(2-hydroxyethyl)amino)-1-methyl-1H-benzimidazole-2-butanoic acid, Bendamustine USP Related Compound E, Bendamustine Monohydroxy Acid Impurity, 4-[5-[2-chloroethyl(2-hydroxyethyl)amino]-1-methyl-benzimidazol-2-yl]butanoic acid

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H340May cause genetic defects
H341Suspected of causing genetic defects
H350May cause cancer
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P264, P270, P280, P301 + P316, P318, P319, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Bendamustine Monohydroxy Impurity?

The CAS Registry Number of Bendamustine Monohydroxy Impurity is 109882-27-1. It is also known as 5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid, 4-{5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H -benzimidazol-2-yl}butanoic acid, Bendamustine Related Compound E (USP).

What is the molecular formula and molecular weight of Bendamustine Monohydroxy Impurity?

Bendamustine Monohydroxy Impurity has the molecular formula C16H22ClN3O3 and a molecular weight of 339.82 g/mol. Its IUPAC name is 4-[5-[2-chloroethyl(2-hydroxyethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid.

What is Bendamustine Monohydroxy Impurity used for?

Bendamustine Monohydroxy Impurity is supplied as a characterised reference material related to Bendamustine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Bendamustine Monohydroxy Impurity can I order?

We supply Bendamustine Monohydroxy Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Bendamustine Monohydroxy Impurity?

Yes. Every lot of Bendamustine Monohydroxy Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Bendamustine Monohydroxy Impurity be shipped internationally?

Yes. Bendamustine Monohydroxy Impurity is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.