Bis(2-chloroethyl)aminophosphoric Dichloride

Name: Bis(2-chloroethyl)aminophosphoric Dichloride
Brand: Vaqora Chemicals
SKU: VQ-036470

About Bis(2-chloroethyl)aminophosphoric Dichloride

Listed under CAS 127-88-8, Bis(2-chloroethyl)aminophosphoric Dichloride is an impurity of Cyclophosphamide available from Vaqora Chemicals. The compound has the formula C4H8Cl4NOP, corresponding to a molecular weight of 258.9 g/mol. The IUPAC name is 2-chloro-N-(2-chloroethyl)-N-dichlorophosphorylethanamine. It is also known as Bis(2-chloroethyl)phosphoramidic dichloride or bis(2-CHLOROETHYL)AMINOPHOSPHONIC DICHLORIDE.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Cyclophosphamide to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Cyclophosphamide

View every impurity, metabolite and intermediate we list for Cyclophosphamide.

Cyclophosphamide impurities

Specifications & identifiers

Chemical identifiers
Product name	Bis(2-chloroethyl)aminophosphoric Dichloride
Catalogue No.	VQ-036470
CAS Number	127-88-8
IUPAC name	2-chloro-N-(2-chloroethyl)-N-dichlorophosphorylethanamine
Molecular formula	C₄H₈Cl₄NOP
Molecular weight	258.9 g/mol
Exact mass	258.9068
Grade	Reference Standard
HSN code	38229090
InChIKey	IQPMYTNILJQKBS-UHFFFAOYSA-N
SMILES	C(CCl)N(CCCl)P(=O)(Cl)Cl
PubChem CID	96271

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	0 / 2
TPSA	20.3 Å²
Synonyms	Bis(2-chloroethyl)phosphoramidic dichloride, Phosphoramidic dichloride, bis(2-chloroethyl)-, bis(2-CHLOROETHYL)AMINOPHOSPHONIC DICHLORIDE, Phosphoramidic dichloride, N,N-bis(2-chloroethyl)-, N,N-Bis(2-chloroethyl)phosphoramidic Dichloride, Phosphoramidicdichloride, N,N-bis(2-chloroethyl)-, N,N-Bis(2-chloroethyl)phosphamide Dichloride, 2-chloro-N-(2-chloroethyl)-N-dichlorophosphoryl-ethanamine, di(2-chloroethyl)phosphoramidic dichloride, Dichlorophosphinic bis(2-chloroethyl)amide, Di-(2-chloroethyl)amidophosphorodichloridate, bis(2-chloroethyl)-phosphoramidic dichloride

Safety & hazard information (GHS)

Corrosive

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H311Toxic in contact with skin
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H331Toxic if inhaled
H351Suspected of causing cancer

Precautionary statements: P203, P260, P261, P262, P264, P270, P271, P272, P280, P301 + P316, P301 + P330 + P331, P302 + P352, P302 + P361 + P354, P304 + P340, P305 + P354 + P338, P316, P318, P321, P330, P333 + P317, P361 + P364, P362 + P364, P363, P403 + P233

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Bis(2-chloroethyl)aminophosphoric Dichloride?

The CAS Registry Number of Bis(2-chloroethyl)aminophosphoric Dichloride is 127-88-8. It is also known as Bis(2-chloroethyl)phosphoramidic dichloride, Phosphoramidic dichloride, bis(2-chloroethyl)-, bis(2-CHLOROETHYL)AMINOPHOSPHONIC DICHLORIDE.

What is the molecular formula and molecular weight of Bis(2-chloroethyl)aminophosphoric Dichloride?

Bis(2-chloroethyl)aminophosphoric Dichloride has the molecular formula C4H8Cl4NOP and a molecular weight of 258.9 g/mol. Its IUPAC name is 2-chloro-N-(2-chloroethyl)-N-dichlorophosphorylethanamine.

What is Bis(2-chloroethyl)aminophosphoric Dichloride used for?

Bis(2-chloroethyl)aminophosphoric Dichloride is supplied as a characterised reference material related to Cyclophosphamide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Bis(2-chloroethyl)aminophosphoric Dichloride can I order?

We supply Bis(2-chloroethyl)aminophosphoric Dichloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Bis(2-chloroethyl)aminophosphoric Dichloride?

Yes. Every lot of Bis(2-chloroethyl)aminophosphoric Dichloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Bis(2-chloroethyl)aminophosphoric Dichloride be shipped internationally?

Yes. Bis(2-chloroethyl)aminophosphoric Dichloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.