Boc-trans-Hydroxy-L-proline

Name: Boc-trans-Hydroxy-L-proline
Brand: Vaqora Chemicals
SKU: VQ-030879

About Boc-trans-Hydroxy-L-proline

Boc-trans-Hydroxy-L-proline (CAS 13726-69-7) is a metabolite or degradation product of Teneligliptin offered by Vaqora Chemicals. Formula C10H17NO5, molecular weight 231.25 g/mol. Its systematic (IUPAC) name is (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid. Alternative names: Boc-Hyp-OH and Boc-L-hydroxyproline.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Teneligliptin, as well as in QC testing and ANDA/DMF documentation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Boc-trans-Hydroxy-L-proline in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Teneligliptin

View every impurity, metabolite and intermediate we list for Teneligliptin.

Teneligliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	Boc-trans-Hydroxy-L-proline
Catalogue No.	VQ-030879
CAS Number	13726-69-7
IUPAC name	(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Molecular formula	C₁₀H₁₇NO₅
Molecular weight	231.25 g/mol
Exact mass	231.1107
Grade	Reference Standard
HSN code	38229090
InChIKey	BENKAPCDIOILGV-RQJHMYQMSA-N
SMILES	CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1C(=O)O)O
PubChem CID	88804

Physical properties
Physical form	Solid
LogP (XLogP3)	0.3
H-bond donors / acceptors	2 / 5
TPSA	87.1 Å²
Synonyms	1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4R), (2S,4R)-4-hydroxy-1-((2-methylpropan-2-yl)oxycarbonyl)pyrrolidine-2-carboxylic acid, 1-(1,1-Dimethylethyl) (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate, Boc-Hyp-OH, Boc-L-hydroxyproline, (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid, N-Boc-trans-4-hydroxy-L-proline, boc-hydroxyproline, (2S,4R)-1-[(Tert-Butoxy)Carbonyl]-4-Hydroxypyrrolidine-2-Carboxylic Acid, (4r)-1-(tert-butoxycarbonyl)-4-hydroxy-l-proline, Boc-trans-4-hydroxy-L-proline, (4R)-1-Boc-4-hydroxy-L-proline

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P317, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Boc-trans-Hydroxy-L-proline?

The CAS Registry Number of Boc-trans-Hydroxy-L-proline is 13726-69-7. It is also known as 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4R), (2S,4R)-4-hydroxy-1-((2-methylpropan-2-yl)oxycarbonyl)pyrrolidine-2-carboxylic acid, 1-(1,1-Dimethylethyl) (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate.

What is the molecular formula and molecular weight of Boc-trans-Hydroxy-L-proline?

Boc-trans-Hydroxy-L-proline has the molecular formula C10H17NO5 and a molecular weight of 231.25 g/mol. Its IUPAC name is (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid.

What is Boc-trans-Hydroxy-L-proline used for?

Boc-trans-Hydroxy-L-proline is supplied as a characterised reference material related to Teneligliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Boc-trans-Hydroxy-L-proline can I order?

We supply Boc-trans-Hydroxy-L-proline in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Boc-trans-Hydroxy-L-proline?

Yes. Every lot of Boc-trans-Hydroxy-L-proline is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Boc-trans-Hydroxy-L-proline be shipped internationally?

Yes. Boc-trans-Hydroxy-L-proline is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.