Cis-Asenapine

Name: Cis-Asenapine
Brand: Vaqora Chemicals
SKU: VQ-013298

About Cis-Asenapine

Cis-Asenapine (CAS 65621-78-5) is a process intermediate or related compound of Asenapine offered by Vaqora Chemicals. Formula C17H16ClNO, molecular weight 285.8 g/mol. Its systematic (IUPAC) name is (2R,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene. Alternative names: Org 5033 and A1BIR.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is a process intermediate or related compound in the synthesis of Asenapine, useful for route development, impurity fate-and-purge studies and analytical method development. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Asenapine

View every impurity, metabolite and intermediate we list for Asenapine.

Asenapine impurities

Specifications & identifiers

Chemical identifiers
Product name	Cis-Asenapine
Catalogue No.	VQ-013298
CAS Number	65621-78-5
IUPAC name	(2R,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene
Molecular formula	C₁₇H₁₆ClNO
Molecular weight	285.8 g/mol
Exact mass	285.092
Grade	Reference Standard
HSN code	2933
InChIKey	VSWBSWWIRNCQIJ-LSDHHAIUSA-N
SMILES	CN1C[C@@H]2[C@H](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24
PubChem CID	14577080

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	0 / 2
TPSA	12.5 Å²
Synonyms	cis-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, Org 5033, 1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, cis-, 1H-Dibenz(2,3:6,7)oxepino(4,5-c)pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, cis-, A1BIR

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Cis-Asenapine?

The CAS Registry Number of Cis-Asenapine is 65621-78-5. It is also known as cis-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, Org 5033, 1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, cis-.

What is the molecular formula and molecular weight of Cis-Asenapine?

Cis-Asenapine has the molecular formula C17H16ClNO and a molecular weight of 285.8 g/mol. Its IUPAC name is (2R,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene.

What is Cis-Asenapine used for?

Cis-Asenapine is supplied as a characterised reference material related to Asenapine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Cis-Asenapine can I order?

We supply Cis-Asenapine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Cis-Asenapine?

Yes. Every lot of Cis-Asenapine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Cis-Asenapine be shipped internationally?

Yes. Cis-Asenapine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.