Dihydroberberine

Name: Dihydroberberine
Brand: Vaqora Chemicals
SKU: VQ-045165

About Dihydroberberine

Dihydroberberine (CAS 483-15-8) is an impurity of Berberine offered by Vaqora Chemicals. Its molecular formula is C20H19NO4 and its molecular weight is 337.4 g/mol. Alternative names: Dihydroumbellatine and 7,8-Dihydroberberine.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 1 hazard statement. Review the Safety Data Sheet before use.

This Berberine impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Berberine

View every impurity, metabolite and intermediate we list for Berberine.

Berberine impurities

Specifications & identifiers

Chemical identifiers
Product name	Dihydroberberine
Catalogue No.	VQ-045165
CAS Number	483-15-8
IUPAC name	16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(21),2,4(8),9,15(20),16,18-heptaene
Molecular formula	C₂₀H₁₉NO₄
Molecular weight	337.4 g/mol
Exact mass	337.1314
Grade	Reference Standard
HSN code	38229090
InChIKey	FZAGOOYMTPGPGF-UHFFFAOYSA-N
SMILES	COC1=C(C2=C(C=C1)C=C3C4=CC5=C(C=C4CCN3C2)OCO5)OC
PubChem CID	10217

Physical properties
Physical form	Solid
LogP (XLogP3)	3.5
H-bond donors / acceptors	0 / 5
TPSA	40.2 Å²
Synonyms	Dihydroumbellatine, 7,8-Dihydroberberine, Dihydroberbine, Lambertine, 9,10-Dimethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline, lambertin, Dihydroberberine/dihydroumbellatine, 3bti, Berberine, dihydro-, 9,10-Dimethoxy-2,3-(methylenedioxy)-13,13a-didehydroberbine, BERBINE, 13,13a-DIDEHYDRO-9,10-DIMETHOXY-2,3-(METHYLENEDIOXY)-, 6H-Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizine, 5,8-dihydro-9,10-dimethoxy-

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Dihydroberberine?

The CAS Registry Number of Dihydroberberine is 483-15-8. It is also known as Dihydroumbellatine, 7,8-Dihydroberberine, Dihydroberbine.

What is the molecular formula and molecular weight of Dihydroberberine?

Dihydroberberine has the molecular formula C20H19NO4 and a molecular weight of 337.4 g/mol. Its IUPAC name is 16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(21),2,4(8),9,15(20),16,18-heptaene.

What is Dihydroberberine used for?

Dihydroberberine is supplied as a characterised reference material related to Berberine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Dihydroberberine can I order?

We supply Dihydroberberine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Dihydroberberine?

Yes. Every lot of Dihydroberberine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Dihydroberberine be shipped internationally?

Yes. Dihydroberberine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.