Encorafenib

Name: Encorafenib
Brand: Vaqora Chemicals
SKU: VQ-007456

About Encorafenib

Encorafenib (CAS 1269440-17-6) is a high-purity reference standard of Encorafenib offered by Vaqora Chemicals. Formula C22H27ClFN7O4S, molecular weight 540.0 g/mol. Alternative names: Braftovi and LGX-818.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Encorafenib standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Encorafenib in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. Stock is available for quick dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Encorafenib

View every impurity, metabolite and intermediate we list for Encorafenib.

Encorafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	Encorafenib
Catalogue No.	VQ-007456
CAS Number	1269440-17-6
IUPAC name	methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate
Molecular formula	C₂₂H₂₇ClFN₇O₄S
Molecular weight	540 g/mol
Exact mass	539.1518
Grade	Reference Standard
HSN code	38229090
InChIKey	CMJCXYNUCSMDBY-ZDUSSCGKSA-N
SMILES	C[C@@H](CNC1=NC=CC(=N1)C2=CN(N=C2C3=C(C(=CC(=C3)Cl)NS(=O)(=O)C)F)C(C)C)NC(=O)OC
PubChem CID	50922675

Physical properties
Physical form	Solid
LogP (XLogP3)	2.7
H-bond donors / acceptors	3 / 10
TPSA	149 Å²
Synonyms	Braftovi, LGX-818, LGX 818, Encorafenib (LGX818), Braftovi (TN), Encorafenib (Standard), LGX-818(Encorafenib), LGX-818(Encorafenib)?, C22H27ClFN7O4S, Encorafenib Refrence standard, Encorafenib (JAN/USAN/INN), EX-A1587

Safety & hazard information (GHS)

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H351Suspected of causing cancer
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H373May causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Encorafenib?

The CAS Registry Number of Encorafenib is 1269440-17-6. It is also known as Braftovi, LGX-818, LGX 818.

What is the molecular formula and molecular weight of Encorafenib?

Encorafenib has the molecular formula C22H27ClFN7O4S and a molecular weight of 540 g/mol. Its IUPAC name is methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate.

What is Encorafenib used for?

Encorafenib is supplied as a characterised reference material related to Encorafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Encorafenib can I order?

We supply Encorafenib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Encorafenib?

Yes. Every lot of Encorafenib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Encorafenib be shipped internationally?

Yes. Encorafenib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.