Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]am… 365997-33-7

Name: Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate
Brand: Vaqora Chemicals
SKU: VQ-036884

About Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate

Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate (CAS 365997-33-7) is a metabolite or degradation product of Edoxaban offered by Vaqora Chemicals. With the molecular formula C14H25NO5, it has a molar mass of 287.35 g/mol. The IUPAC name is ethyl (1S,3R,4R)-4-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylate.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Edoxaban, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Edoxaban

View every impurity, metabolite and intermediate we list for Edoxaban.

Edoxaban impurities

Specifications & identifiers

Chemical identifiers
Product name	Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate
Catalogue No.	VQ-036884
CAS Number	365997-33-7
IUPAC name	ethyl (1S,3R,4R)-4-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylate
Molecular formula	C₁₄H₂₅NO₅
Molecular weight	287.35 g/mol
Exact mass	287.1733
Grade	Reference Standard
HSN code	38229090
InChIKey	YFFMJGAVWORNIZ-HBNTYKKESA-N
SMILES	CCOC(=O)[C@H]1CC[C@H]([C@@H](C1)NC(=O)OC(C)(C)C)O
PubChem CID	59676815

Physical properties
Physical form	Solid
LogP (XLogP3)	1.4
H-bond donors / acceptors	2 / 5
TPSA	84.9 Å²
Synonyms	(1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester, (1S,3R,4R)-Ethyl 3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexanecarboxylate, (1S,3R,4R)-ethyl 3-((Boc)amino)-4-hydroxycyclohexanecarboxylate, Ethyl (1S,3R,4R)-3-(Boc-amino)-4-hydroxycyclohexanecarboxylate, (1S,3r,4r)-3-(boc-amino)-4-hydroxy-cyclohexanecarboxylicacid ethyl ester, (1S,3R,4R)-ethyl 3-(tert-butoxycarbonylamino)-4-hydroxycyclohexanecarboxylate, (1S,3R,4R)-Ethyl3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexanecarboxylate, ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxy-cyclohexanecarboxylate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate?

The CAS Registry Number of Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate is 365997-33-7. It is also known as (1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester, (1S,3R,4R)-Ethyl 3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexanecarboxylate, (1S,3R,4R)-ethyl 3-((Boc)amino)-4-hydroxycyclohexanecarboxylate.

What is the molecular formula and molecular weight of Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate?

Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate has the molecular formula C14H25NO5 and a molecular weight of 287.35 g/mol. Its IUPAC name is ethyl (1S,3R,4R)-4-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylate.

What is Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate used for?

Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate is supplied as a characterised reference material related to Edoxaban. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate can I order?

We supply Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate?

Yes. Every lot of Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate be shipped internationally?

Yes. Ethyl (1S,3R,4R)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclohexane-1-carboxylate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.