Glasdegib

Name: Glasdegib
Brand: Vaqora Chemicals
SKU: VQ-030997

About Glasdegib

Glasdegib (CAS 1095173-27-5) is an API reference standard offered by Vaqora Chemicals. Formula C21H22N6O, molecular weight 374.4 g/mol. The IUPAC name is 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea. It is also known as EX-A858 or PF-913.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 3 hazard statements. Review the Safety Data Sheet before use.

As a reference sample of the parent drug substance, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Glasdegib in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Specifications & identifiers

Chemical identifiers
Product name	Glasdegib
Catalogue No.	VQ-030997
CAS Number	1095173-27-5
IUPAC name	1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea
Molecular formula	C₂₁H₂₂N₆O
Molecular weight	374.4 g/mol
Exact mass	374.1855
Grade	Reference Standard
HSN code	38229090
InChIKey	SFNSLLSYNZWZQG-VQIMIIECSA-N
SMILES	CN1CC[C@H](C[C@@H]1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N
PubChem CID	25166913

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	3 / 4
TPSA	96.8 Å²
Synonyms	N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)urea, 3-[(2R,4R)-2-(1H-1,3-benzodiazol-2-yl)-1-methylpiperidin-4-yl]-1-(4-cyanophenyl)urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-N'-(4-cyanophenyl)urea, 1-((2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea, 3-((2R,4R)-2-(1H-1,3-benzodiazol-2-yl)-1-methylpiperidin-4-yl)-1-(4-cyanophenyl)urea, N-((2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl)-N'-(4-cyanophenyl)urea, 1-((2R,4R)-2-(1H-benzo[d]iMidazol-2-yl)-1-Methylpiperidin-4-yl)-3-(4-cyanophenyl)urea, EX-A858, Urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)-, PF-913, 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidyl]-3-(4-cyanophenyl)urea

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P280, P318, P319, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Glasdegib?

The CAS Registry Number of Glasdegib is 1095173-27-5. It is also known as N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)urea, 3-[(2R,4R)-2-(1H-1,3-benzodiazol-2-yl)-1-methylpiperidin-4-yl]-1-(4-cyanophenyl)urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-N'-(4-cyanophenyl)urea.

What is the molecular formula and molecular weight of Glasdegib?

Glasdegib has the molecular formula C21H22N6O and a molecular weight of 374.4 g/mol. Its IUPAC name is 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea.

Which grade and pack sizes of Glasdegib can I order?

We supply Glasdegib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Glasdegib?

Yes. Every lot of Glasdegib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Glasdegib be shipped internationally?

Yes. Glasdegib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.