N-Chlorophthalimide

Name: N-Chlorophthalimide
Brand: Vaqora Chemicals
SKU: VQ-036272

About N-Chlorophthalimide

N-Chlorophthalimide is a process intermediate or related compound of Rivaroxaban carrying the CAS registry number 3481-09-2. Its molecular formula is C8H4ClNO2 and its molecular weight is 181.57 g/mol. Systematically, it is named 2-chloroisoindole-1,3-dione. It is also known as 2-Chloroisoindoline-1,3-dione or 1H-Isoindole-1,3(2H)-dione, 2-chloro-.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

Process chemists and analysts use it when developing synthetic routes to Rivaroxaban, tracking process-related impurities and validating analytical methods. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, N-Chlorophthalimide is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development
Fine chemical synthesis

Industries

Related to Rivaroxaban

View every impurity, metabolite and intermediate we list for Rivaroxaban.

Rivaroxaban impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Chlorophthalimide
Catalogue No.	VQ-036272
CAS Number	3481-09-2
IUPAC name	2-chloroisoindole-1,3-dione
Molecular formula	C₈H₄ClNO₂
Molecular weight	181.57 g/mol
Exact mass	180.9931
HSN code	2933
InChIKey	WDRFYIPWHMGQPN-UHFFFAOYSA-N
SMILES	C1=CC=C2C(=C1)C(=O)N(C2=O)Cl
PubChem CID	18997

Physical properties
Physical form	Solid
LogP (XLogP3)	1.5
H-bond donors / acceptors	0 / 2
TPSA	37.4 Å²
Synonyms	2-Chloroisoindoline-1,3-dione, 1H-Isoindole-1,3(2H)-dione, 2-chloro-, Chlorophtalimide, Phthalimide chloride, Phthalimide, N-chloro-, n-chlorphthalimid, 2-chloranylisoindole-1,3-dione, 2-chloro-1h-isoindole-1,3(2h)-dione, 1H-Isoindole-1, 2-chloro-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Chlorophthalimide?

The CAS Registry Number of N-Chlorophthalimide is 3481-09-2. It is also known as 2-Chloroisoindoline-1,3-dione, 1H-Isoindole-1,3(2H)-dione, 2-chloro-, Chlorophtalimide.

What is the molecular formula and molecular weight of N-Chlorophthalimide?

N-Chlorophthalimide has the molecular formula C8H4ClNO2 and a molecular weight of 181.57 g/mol. Its IUPAC name is 2-chloroisoindole-1,3-dione.

What is N-Chlorophthalimide used for?

N-Chlorophthalimide is supplied as a characterised reference material related to Rivaroxaban. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Chlorophthalimide can I order?

We supply N-Chlorophthalimide, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Chlorophthalimide?

Yes. Every lot of N-Chlorophthalimide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Chlorophthalimide be shipped internationally?

Yes. N-Chlorophthalimide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.