N-Desmethyl Sorafenib

Name: N-Desmethyl Sorafenib
Brand: Vaqora Chemicals
SKU: VQ-033923

About N-Desmethyl Sorafenib

N-Desmethyl Sorafenib (CAS 284461-74-1) is a metabolite or degradation product of Sorafenib offered by Vaqora Chemicals. The compound has the formula C20H14ClF3N4O3, corresponding to a molecular weight of 450.8 g/mol. Systematically, it is named 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide. Alternative names: Sorafenib metabolite M4.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Sorafenib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Sorafenib

View every impurity, metabolite and intermediate we list for Sorafenib.

Sorafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl Sorafenib
Catalogue No.	VQ-033923
CAS Number	284461-74-1
IUPAC name	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide
Molecular formula	C₂₀H₁₄ClF₃N₄O₃
Molecular weight	450.8 g/mol
Exact mass	450.0707
Grade	Reference Standard
HSN code	38229090
InChIKey	UAEWBZYTKIMYRQ-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=CC(=NC=C3)C(=O)N
PubChem CID	10151557

Physical properties
Physical form	Solid
LogP (XLogP3)	3.7
H-bond donors / acceptors	3 / 7
TPSA	106 Å²
Synonyms	4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide, Sorafenib metabolite M4, n-(4-chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-carbamoyl-4-pyridyloxy)phenyl)urea, 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]pyridine-2-carboxamide, 1-(4-(2-carbamoylpyridin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{4-[2-carbamoyl-(4-pyridyloxy)]phenyl} urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{4-[2-carbamoyl-(4-pyridyloxy)]phenyl}urea, N-[4-chloro-3-(trifluoromethyl)phenyl]N'-{4-[2-carbamoyl-(4-pyridyloxy)]phenyl}urea

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl Sorafenib?

The CAS Registry Number of N-Desmethyl Sorafenib is 284461-74-1. It is also known as 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide, Sorafenib metabolite M4, n-(4-chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-carbamoyl-4-pyridyloxy)phenyl)urea.

What is the molecular formula and molecular weight of N-Desmethyl Sorafenib?

N-Desmethyl Sorafenib has the molecular formula C20H14ClF3N4O3 and a molecular weight of 450.8 g/mol. Its IUPAC name is 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide.

What is N-Desmethyl Sorafenib used for?

N-Desmethyl Sorafenib is supplied as a characterised reference material related to Sorafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl Sorafenib can I order?

We supply N-Desmethyl Sorafenib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl Sorafenib?

Yes. Every lot of N-Desmethyl Sorafenib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl Sorafenib be shipped internationally?

Yes. We export N-Desmethyl Sorafenib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.