N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)e… 1348044-24-5

Name: N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide
Brand: Vaqora Chemicals
SKU: VQ-029312

About N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide

Vaqora Chemicals supplies N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide, an impurity of Axitinib registered under CAS number 1348044-24-5. Formula C22H18N4O3S, molecular weight 418.5 g/mol. Its systematic (IUPAC) name is 2-[(3E)-3-[(2E)-2-(1-hydroxy-2-pyridinylidene)ethylidene]indazol-6-yl]sulfinyl-N-methylbenzamide. It is also known as Axitinib metabolite M9 or Axitinib sulfoxide pyridine-N-oxide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

As a characterised impurity of Axitinib, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Axitinib

View every impurity, metabolite and intermediate we list for Axitinib.

Axitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide
Catalogue No.	VQ-029312
CAS Number	1348044-24-5
IUPAC name	2-[(3E)-3-[(2E)-2-(1-hydroxy-2-pyridinylidene)ethylidene]indazol-6-yl]sulfinyl-N-methylbenzamide
Molecular formula	C₂₂H₁₈N₄O₃S
Molecular weight	418.5 g/mol
Exact mass	418.11
Grade	Reference Standard
HSN code	38229090
InChIKey	MESVCUNKPBREDN-UUAZFVJBSA-N
SMILES	CNC(=O)C1=CC=CC=C1S(=O)C2=CC3=C(C=C2)/C(=C\C=C\4/C=CC=CN4O)/N=N3
PubChem CID	146675116

Physical properties
Physical form	Solid
LogP (XLogP3)	3.3
H-bond donors / acceptors	2 / 7
TPSA	114 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide?

The CAS Registry Number of N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide is 1348044-24-5. It is also known as Axitinib metabolite M9, Axitinib sulfoxide pyridine-N-oxide, Benzamide, N-methyl-2-((3-((1E)-2-(1-oxido-2-pyridinyl)ethenyl)-1H-indazol-6-yl)sulfinyl)-.

What is the molecular formula and molecular weight of N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide?

N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide has the molecular formula C22H18N4O3S and a molecular weight of 418.5 g/mol. Its IUPAC name is 2-[(3E)-3-[(2E)-2-(1-hydroxy-2-pyridinylidene)ethylidene]indazol-6-yl]sulfinyl-N-methylbenzamide.

What is N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide used for?

N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide is supplied as a characterised reference material related to Axitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide can I order?

We supply N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide?

Yes. Every lot of N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide be shipped internationally?

Yes. We export N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.