N-Nitroso Sotalol (Rotamers)

Name: N-Nitroso Sotalol (Rotamers)
Brand: Vaqora Chemicals
SKU: VQ-006958

About N-Nitroso Sotalol (Rotamers)

Listed under CAS 134720-07-3, N-Nitroso Sotalol (Rotamers) is a nitrosamine impurity of Sotalol available from Vaqora Chemicals with a typical assay of 97%. Its molecular formula is C12H19N3O4S and its molecular weight is 301.36 g/mol. The IUPAC name is N-[4-[1-hydroxy-2-[nitroso(propan-2-yl)amino]ethyl]phenyl]methanesulfonamide. It is also known as N-Nitrososotalol or N-nitroso-sotalol.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, N-Nitroso Sotalol (Rotamers) is dispatched with a Certificate of Analysis (COA) to destinations worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Sotalol

View every impurity, metabolite and intermediate we list for Sotalol.

Sotalol impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso Sotalol (Rotamers)
Catalogue No.	VQ-006958
CAS Number	134720-07-3
IUPAC name	N-[4-[1-hydroxy-2-[nitroso(propan-2-yl)amino]ethyl]phenyl]methanesulfonamide
Molecular formula	C₁₂H₁₉N₃O₄S
Molecular weight	301.36 g/mol
Exact mass	301.1096
Grade	Reference Standard
Purity / assay	97%
HSN code	38229090
InChIKey	JRGLEYZCDAJXQF-UHFFFAOYSA-N
SMILES	CC(C)N(CC(C1=CC=C(C=C1)NS(=O)(=O)C)O)N=O
PubChem CID	154451

Physical properties
Physical form	Solid
LogP (XLogP3)	0.8
H-bond donors / acceptors	2 / 7
TPSA	107 Å²
Synonyms	N-Nitrososotalol, N-(4-(1-Hydroxy-2-(isopropyl(nitroso)amino)ethyl)phenyl)methanesulfonamide, N-[4-[1-Hydroxy-2-[(1-methylethyl)nitrosoamino]ethyl]phenyl]methanesulfonamide, N-(4-{1-Hydroxy-2-[nitroso(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide, N-(4-(1-hydroxy-2-(nitroso(propan-2-yl)amino)ethyl)phenyl)methanesulfonamide, N-nitroso-sotalol, N-(4-(1-Hydroxy-2-((1-methylethyl)nitrosoamino)ethyl)phenyl)methanesulfonamide, Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)nitrosoamino)ethyl)phenyl)-, Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)nitrosoamino]ethyl]phenyl]-, N-Nitrososotalol 0.1 mg/ml in Methanol

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P321, P330, P332 + P317, P337 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso Sotalol (Rotamers)?

The CAS Registry Number of N-Nitroso Sotalol (Rotamers) is 134720-07-3. It is also known as N-Nitrososotalol, N-(4-(1-Hydroxy-2-(isopropyl(nitroso)amino)ethyl)phenyl)methanesulfonamide, N-[4-[1-Hydroxy-2-[(1-methylethyl)nitrosoamino]ethyl]phenyl]methanesulfonamide.

What is the molecular formula and molecular weight of N-Nitroso Sotalol (Rotamers)?

N-Nitroso Sotalol (Rotamers) has the molecular formula C12H19N3O4S and a molecular weight of 301.36 g/mol. Its IUPAC name is N-[4-[1-hydroxy-2-[nitroso(propan-2-yl)amino]ethyl]phenyl]methanesulfonamide.

What is N-Nitroso Sotalol (Rotamers) used for?

N-Nitroso Sotalol (Rotamers) is supplied as a characterised reference material related to Sotalol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso Sotalol (Rotamers) can I order?

We supply N-Nitroso Sotalol (Rotamers) in Reference Standard (97%) grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso Sotalol (Rotamers)?

Yes. Every lot of N-Nitroso Sotalol (Rotamers) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso Sotalol (Rotamers) be shipped internationally?

Yes. N-Nitroso Sotalol (Rotamers) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.