Nalbuphine

Name: Nalbuphine
Brand: Vaqora Chemicals
SKU: VQ-044029

About Nalbuphine

Nalbuphine is a high-purity reference standard of Nalbuphine carrying the CAS registry number 20594-83-6. The compound has the formula C21H27NO4, corresponding to a molecular weight of 357.4 g/mol. Alternative names: Nalbufina [DCIT].

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

Laboratories use this Nalbuphine standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Nalbuphine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Nalbuphine

View every impurity, metabolite and intermediate we list for Nalbuphine.

Nalbuphine impurities

Specifications & identifiers

Chemical identifiers
Product name	Nalbuphine
Catalogue No.	VQ-044029
CAS Number	20594-83-6
IUPAC name	(4R,4aS,7S,7aR,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol
Molecular formula	C₂₁H₂₇NO₄
Molecular weight	357.4 g/mol
Exact mass	357.194
Grade	Reference Standard
HSN code	38229090
InChIKey	NETZHAKZCGBWSS-CEDHKZHLSA-N
SMILES	C1CC(C1)CN2CC[C@]34[C@@H]5[C@H](CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O)O
PubChem CID	5311304

Physical properties
Physical form	Solid
LogP (XLogP3)	0.2
H-bond donors / acceptors	3 / 5
TPSA	73.2 Å²
Synonyms	N-Cyclobutylmethyl-4,5alpha-epoxy-3,6alpha,14-morphinantriol, 17-(Cyclobutylmethyl)-4,5alpha-epoxymorphinan-3,6alpha,14-triol, Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, (5alpha,6alpha)-, 17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alpha,14-triol, Nalbufina [DCIT], (5alpha,6alpha)-17-(cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol, Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, 17-(Cyclobutylmethyl)-5alpha-4,5-epoxymorphinan-3,6alpha,14-triol, (-)-17-(cyclobutylmethyl)-4,5alpha-epoxymorphinan-3,6alpha,14-triol

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H332Harmful if inhaled
H336May cause drowsiness or dizziness

Precautionary statements: P261, P264, P270, P271, P301 + P317, P304 + P340, P317, P319, P330, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nalbuphine?

The CAS Registry Number of Nalbuphine is 20594-83-6. It is also known as N-Cyclobutylmethyl-4,5alpha-epoxy-3,6alpha,14-morphinantriol, 17-(Cyclobutylmethyl)-4,5alpha-epoxymorphinan-3,6alpha,14-triol, Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, (5alpha,6alpha)-.

What is the molecular formula and molecular weight of Nalbuphine?

Nalbuphine has the molecular formula C21H27NO4 and a molecular weight of 357.4 g/mol. Its IUPAC name is (4R,4aS,7S,7aR,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol.

What is Nalbuphine used for?

Nalbuphine is supplied as a characterised reference material related to Nalbuphine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nalbuphine can I order?

We supply Nalbuphine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nalbuphine?

Yes. Every lot of Nalbuphine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nalbuphine be shipped internationally?

Yes. Nalbuphine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.