Nirogacestat

Name: Nirogacestat
Brand: Vaqora Chemicals
SKU: VQ-007620

About Nirogacestat

Vaqora Chemicals supplies Nirogacestat, a high-purity reference standard of Nirogacestat registered under CAS number 1290543-63-3. With the molecular formula C27H41F2N5O, it has a molar mass of 489.6 g/mol. Alternative names: Nirogacestat (USAN/INN) and EX-A855.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Nirogacestat standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Nirogacestat is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Nirogacestat

View every impurity, metabolite and intermediate we list for Nirogacestat.

Nirogacestat impurities

Specifications & identifiers

Chemical identifiers
Product name	Nirogacestat
Catalogue No.	VQ-007620
CAS Number	1290543-63-3
Other CAS	2664906-78-7, 1962925-29-6
IUPAC name	(2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide
Molecular formula	C₂₇H₄₁F₂N₅O
Molecular weight	489.6 g/mol
Exact mass	489.3279
Grade	Reference Standard
HSN code	38229090
InChIKey	VFCRKLWBYMDAED-REWPJTCUSA-N
SMILES	CCC[C@@H](C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)N[C@H]2CCC3=C(C2)C(=CC(=C3)F)F
PubChem CID	46224413

Physical properties
Physical form	Solid
LogP (XLogP3)	4.8
H-bond donors / acceptors	3 / 6
TPSA	71 Å²
Synonyms	Nirogacestat (USAN/INN), EX-A855, PF-3084014 (y-secratase), EX-A7114, O6U

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nirogacestat?

The CAS Registry Number of Nirogacestat is 1290543-63-3. It is also known as Nirogacestat (USAN/INN), EX-A855, PF-3084014 (y-secratase).

What is the molecular formula and molecular weight of Nirogacestat?

Nirogacestat has the molecular formula C27H41F2N5O and a molecular weight of 489.6 g/mol. Its IUPAC name is (2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide.

What is Nirogacestat used for?

Nirogacestat is supplied as a characterised reference material related to Nirogacestat. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nirogacestat can I order?

We supply Nirogacestat in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nirogacestat?

Yes. Every lot of Nirogacestat is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nirogacestat be shipped internationally?

Yes. Nirogacestat is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.