Orthocaine

Name: Orthocaine
Brand: Vaqora Chemicals
SKU: VQ-049689

About Orthocaine

Listed under CAS 536-25-4, Orthocaine is a process intermediate or related compound of Proxymetacaine available from Vaqora Chemicals. The compound has the formula C8H9NO3, corresponding to a molecular weight of 167.16 g/mol. The IUPAC name is methyl 3-amino-4-hydroxybenzoate. It is also known as methyl 3-amino-4-hydroxy-benzoate or 3-Amino-4-hydroxybenzoic acid methyl ester.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

Process chemists and analysts use it when developing synthetic routes to Proxymetacaine, tracking process-related impurities and validating analytical methods. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Orthocaine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Proxymetacaine

View every impurity, metabolite and intermediate we list for Proxymetacaine.

Proxymetacaine impurities

Specifications & identifiers

Chemical identifiers
Product name	Orthocaine
Catalogue No.	VQ-049689
CAS Number	536-25-4
IUPAC name	methyl 3-amino-4-hydroxybenzoate
Molecular formula	C₈H₉NO₃
Molecular weight	167.16 g/mol
Exact mass	167.0582
HSN code	2933
InChIKey	VNQABZCSYCTZMS-UHFFFAOYSA-N
SMILES	COC(=O)C1=CC(=C(C=C1)O)N
PubChem CID	10815

Physical properties
Physical form	Solid
LogP (XLogP3)	1
H-bond donors / acceptors	2 / 4
TPSA	72.6 Å²
Synonyms	methyl 3-amino-4-hydroxy-benzoate, 3-Amino-4-hydroxybenzoic acid methyl ester, Methyl m-amino-p-hydroxybenzoate, Methyl 4-hydroxy-3-aminobenzoate, Methyl 3-amino-4-hydroxybenzenecarboxylate, Orthoform new, Methyl-3-amino-4-hydroxybenzoate, Mehyl3-amino-4-hydroxybenzoate, Mehyl 3-amino-4-hydroxybenzoate, 2-amino-4-methoxycarbonylphenol, m-Amino-p-oxybenzoesauremethylester, methyl 3-amino-4-hydroxybenzoate, AldrichCPR

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Orthocaine?

The CAS Registry Number of Orthocaine is 536-25-4. It is also known as methyl 3-amino-4-hydroxy-benzoate, 3-Amino-4-hydroxybenzoic acid methyl ester, Methyl m-amino-p-hydroxybenzoate.

What is the molecular formula and molecular weight of Orthocaine?

Orthocaine has the molecular formula C8H9NO3 and a molecular weight of 167.16 g/mol. Its IUPAC name is methyl 3-amino-4-hydroxybenzoate.

What is Orthocaine used for?

Orthocaine is supplied as a characterised reference material related to Proxymetacaine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Orthocaine can I order?

We supply Orthocaine, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Orthocaine?

Yes. Every lot of Orthocaine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Orthocaine be shipped internationally?

Yes. Orthocaine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.