Pemetrexed Impurity D(Free Base)

Name: Pemetrexed Impurity D(Free Base)
Brand: Vaqora Chemicals
SKU: VQ-005507

About Pemetrexed Impurity D(Free Base)

Vaqora Chemicals supplies Pemetrexed Impurity D(Free Base), an impurity of Pemetrexed registered under CAS number 144051-68-3. Formula C25H28N6O9, molecular weight 556.5 g/mol. Alternative names: Pemetrexed Impurity D (Free Base) and Pemetrexed L-Glutamic Acid.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 6 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Pemetrexed, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Pemetrexed Impurity D(Free Base) in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Pemetrexed

View every impurity, metabolite and intermediate we list for Pemetrexed.

Pemetrexed impurities

Specifications & identifiers

Chemical identifiers
Product name	Pemetrexed Impurity D(Free Base)
Catalogue No.	VQ-005507
CAS Number	144051-68-3
Other CAS	1265908-59-5
IUPAC name	(2S)-2-[[(4S)-4-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]-4-carboxybutanoyl]amino]pentanedioic acid
Molecular formula	C₂₅H₂₈N₆O₉
Molecular weight	556.5 g/mol
Exact mass	556.1918
Grade	Reference Standard
HSN code	38229090
InChIKey	COZFORXRWZIVED-HOTGVXAUSA-N
SMILES	C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)O
PubChem CID	135877968

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.5
H-bond donors / acceptors	8 / 10
TPSA	253 Å²
Synonyms	Pemetrexed Impurity D (Free Base), Pemetrexed L-Glutamic Acid, Pemetrexed disodium heptahydrate impurity D, Pemetrexed EP Impurity D, Pemetrexed Impurity D

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H341Suspected of causing genetic defects
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P264, P264 + P265, P270, P280, P302 + P352, P305 + P351 + P338, P318, P319, P321, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Pemetrexed Impurity D(Free Base)?

The CAS Registry Number of Pemetrexed Impurity D(Free Base) is 144051-68-3. It is also known as Pemetrexed Impurity D (Free Base), Pemetrexed L-Glutamic Acid, Pemetrexed disodium heptahydrate impurity D.

What is the molecular formula and molecular weight of Pemetrexed Impurity D(Free Base)?

Pemetrexed Impurity D(Free Base) has the molecular formula C25H28N6O9 and a molecular weight of 556.5 g/mol. Its IUPAC name is (2S)-2-[[(4S)-4-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]-4-carboxybutanoyl]amino]pentanedioic acid.

What is Pemetrexed Impurity D(Free Base) used for?

Pemetrexed Impurity D(Free Base) is supplied as a characterised reference material related to Pemetrexed. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Pemetrexed Impurity D(Free Base) can I order?

We supply Pemetrexed Impurity D(Free Base) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Pemetrexed Impurity D(Free Base)?

Yes. Every lot of Pemetrexed Impurity D(Free Base) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Pemetrexed Impurity D(Free Base) be shipped internationally?

Yes. Pemetrexed Impurity D(Free Base) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.