Podophyllotoxone

Name: Podophyllotoxone
Brand: Vaqora Chemicals
SKU: VQ-030625

About Podophyllotoxone

Listed under CAS 477-49-6, Podophyllotoxone is an impurity of Podophyllotoxin available from Vaqora Chemicals. The compound has the formula C22H20O8, corresponding to a molecular weight of 412.4 g/mol. Its systematic (IUPAC) name is (5aR,8aR,9R)-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-[2]benzofuro[5,6-f][1,3]benzodioxole-5,8-dione. It is also known as Podophyllotoxinone or SureCN986475.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Podophyllotoxin, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Podophyllotoxone is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Podophyllotoxin

View every impurity, metabolite and intermediate we list for Podophyllotoxin.

Podophyllotoxin impurities

Specifications & identifiers

Chemical identifiers
Product name	Podophyllotoxone
Catalogue No.	VQ-030625
CAS Number	477-49-6
IUPAC name	(5aR,8aR,9R)-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-[2]benzofuro[5,6-f][1,3]benzodioxole-5,8-dione
Molecular formula	C₂₂H₂₀O₈
Molecular weight	412.4 g/mol
Exact mass	412.1158
Grade	Reference Standard
HSN code	38229090
InChIKey	ISCQYPPCSYRZOT-BKTGTZMESA-N
SMILES	COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)C(=O)C4=CC5=C(C=C24)OCO5
PubChem CID	443014

Physical properties
Physical form	Solid
LogP (XLogP3)	2.5
H-bond donors / acceptors	0 / 8
TPSA	89.5 Å²

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Podophyllotoxone?

The CAS Registry Number of Podophyllotoxone is 477-49-6. It is also known as Podophyllotoxinone, SureCN986475.

What is the molecular formula and molecular weight of Podophyllotoxone?

Podophyllotoxone has the molecular formula C22H20O8 and a molecular weight of 412.4 g/mol. Its IUPAC name is (5aR,8aR,9R)-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-[2]benzofuro[5,6-f][1,3]benzodioxole-5,8-dione.

What is Podophyllotoxone used for?

Podophyllotoxone is supplied as a characterised reference material related to Podophyllotoxin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Podophyllotoxone can I order?

We supply Podophyllotoxone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Podophyllotoxone?

Yes. Every lot of Podophyllotoxone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Podophyllotoxone be shipped internationally?

Yes. Podophyllotoxone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.