Sitagliptin Impurity 18

Name: Sitagliptin Impurity 18
Brand: Vaqora Chemicals
SKU: VQ-042209

About Sitagliptin Impurity 18

Vaqora Chemicals supplies Sitagliptin Impurity 18, an impurity of Sitagliptin registered under CAS number 1481965-39-2. With the molecular formula C6H6F3N5O, it has a molar mass of 221.14 g/mol. Systematically, it is named 7-nitroso-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine. Alternative names: Nitroso-STG-19 and Sitagliptin Nttp Impurity.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Sitagliptin, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Sitagliptin Impurity 18 in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sitagliptin

View every impurity, metabolite and intermediate we list for Sitagliptin.

Sitagliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	Sitagliptin Impurity 18
Catalogue No.	VQ-042209
CAS Number	1481965-39-2
IUPAC name	7-nitroso-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine
Molecular formula	C₆H₆F₃N₅O
Molecular weight	221.14 g/mol
Exact mass	221.0524
Grade	Reference Standard
HSN code	38229090
InChIKey	HPLUAAVIJHAQQZ-UHFFFAOYSA-N
SMILES	C1CN2C(=NN=C2C(F)(F)F)CN1N=O
PubChem CID	165984324

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.1
H-bond donors / acceptors	0 / 8
TPSA	63.4 Å²
Synonyms	7-Nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, 7-nitroso-3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine, Nitroso-STG-19, 7-Nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo-[4,3-a]pyrazine, 1,2,4-Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-7-nitroso-3-(trifluoromethyl)-, Sitagliptin Nttp Impurity, Sitagliptin Impurity 174, N-NitrosoSitagliptinImpurity, N-Nitroso Sitagliptin Amine, Nitroso-sitagliptin STG-19, Nitroso-STG-19 (Sitagliptin), N-Nitroso Sitagliptin Impurity 20

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Sitagliptin Impurity 18?

The CAS Registry Number of Sitagliptin Impurity 18 is 1481965-39-2. It is also known as 7-Nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, 7-nitroso-3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine, Nitroso-STG-19.

What is the molecular formula and molecular weight of Sitagliptin Impurity 18?

Sitagliptin Impurity 18 has the molecular formula C6H6F3N5O and a molecular weight of 221.14 g/mol. Its IUPAC name is 7-nitroso-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine.

What is Sitagliptin Impurity 18 used for?

Sitagliptin Impurity 18 is supplied as a characterised reference material related to Sitagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Sitagliptin Impurity 18 can I order?

We supply Sitagliptin Impurity 18 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Sitagliptin Impurity 18?

Yes. Every lot of Sitagliptin Impurity 18 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Sitagliptin Impurity 18 be shipped internationally?

Yes. Sitagliptin Impurity 18 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.