Tert-Butyl O-(tert-butyl)-D-threoninate

Name: Tert-Butyl O-(tert-butyl)-D-threoninate
Brand: Vaqora Chemicals
SKU: VQ-051136

About Tert-Butyl O-(tert-butyl)-D-threoninate

Tert-Butyl O-(tert-butyl)-D-threoninate is a process intermediate or related compound of Threonine carrying the CAS registry number 685087-27-8. Its molecular formula is C12H25NO3 and its molecular weight is 231.33 g/mol. Its systematic (IUPAC) name is tert-butyl (2R,3S)-2-amino-3-[(2-methylpropan-2-yl)oxy]butanoate. Common synonyms include H-D-Thr(tBu)-OtBu and H-D-Thr(tBu)-OtBu (Syrup).

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Process chemists and analysts use it when developing synthetic routes to Threonine, tracking process-related impurities and validating analytical methods. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Threonine

View every impurity, metabolite and intermediate we list for Threonine.

Threonine impurities

Specifications & identifiers

Chemical identifiers
Product name	Tert-Butyl O-(tert-butyl)-D-threoninate
Catalogue No.	VQ-051136
CAS Number	685087-27-8
IUPAC name	tert-butyl (2R,3S)-2-amino-3-[(2-methylpropan-2-yl)oxy]butanoate
Molecular formula	C₁₂H₂₅NO₃
Molecular weight	231.33 g/mol
Exact mass	231.1834
InChIKey	PPDIUNOGUIAFLV-DTWKUNHWSA-N
SMILES	C[C@@H]([C@H](C(=O)OC(C)(C)C)N)OC(C)(C)C
PubChem CID	92963439

Physical properties
Physical form	Solid
LogP (XLogP3)	1.5
H-bond donors / acceptors	1 / 4
TPSA	61.6 Å²
Synonyms	H-D-Thr(tBu)-OtBu, (2R,3S)-tert-Butyl 2-amino-3-(tert-butoxy)butanoate, tert-butyl (2R,3S)-2-amino-3-(tert-butoxy)butanoate, H-D-Thr(tBu)-OtBu (Syrup), o-(1,1-Dimethylethyl)-D-threonine tert-butyl ester, O-(1,1-Dimethylethyl)-D-threonine 1,1-dimethylethyl ester

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H227Combustible liquid
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation

Precautionary statements: P210, P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P319, P321, P332 + P317, P362 + P364, P370 + P378, P403, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tert-Butyl O-(tert-butyl)-D-threoninate?

The CAS Registry Number of Tert-Butyl O-(tert-butyl)-D-threoninate is 685087-27-8. It is also known as H-D-Thr(tBu)-OtBu, (2R,3S)-tert-Butyl 2-amino-3-(tert-butoxy)butanoate, tert-butyl (2R,3S)-2-amino-3-(tert-butoxy)butanoate.

What is the molecular formula and molecular weight of Tert-Butyl O-(tert-butyl)-D-threoninate?

Tert-Butyl O-(tert-butyl)-D-threoninate has the molecular formula C12H25NO3 and a molecular weight of 231.33 g/mol. Its IUPAC name is tert-butyl (2R,3S)-2-amino-3-[(2-methylpropan-2-yl)oxy]butanoate.

What is Tert-Butyl O-(tert-butyl)-D-threoninate used for?

Tert-Butyl O-(tert-butyl)-D-threoninate is supplied as a characterised reference material related to Threonine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tert-Butyl O-(tert-butyl)-D-threoninate can I order?

We supply Tert-Butyl O-(tert-butyl)-D-threoninate, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tert-Butyl O-(tert-butyl)-D-threoninate?

Yes. Every lot of Tert-Butyl O-(tert-butyl)-D-threoninate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tert-Butyl O-(tert-butyl)-D-threoninate be shipped internationally?

Yes. Tert-Butyl O-(tert-butyl)-D-threoninate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.