trans-4-Hydroxy-D-proline

Name: trans-4-Hydroxy-D-proline
Brand: Vaqora Chemicals
SKU: VQ-049986

About trans-4-Hydroxy-D-proline

Listed under CAS 3398-22-9, trans-4-Hydroxy-D-proline is a metabolite / degradant standard available from Vaqora Chemicals. With the molecular formula C5H9NO3, it has a molar mass of 131.13 g/mol. The IUPAC name is (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid. Alternative names: H-D-Hyp-OH and (4S)-4-hydroxy-D-proline.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

It is used in metabolite identification, stability-indicating method development and impurity profiling, as well as in QC testing and ANDA/DMF documentation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, trans-4-Hydroxy-D-proline is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Specifications & identifiers

Chemical identifiers
Product name	trans-4-Hydroxy-D-proline
Catalogue No.	VQ-049986
CAS Number	3398-22-9
IUPAC name	(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid
Molecular formula	C₅H₉NO₃
Molecular weight	131.13 g/mol
Exact mass	131.0582
Grade	Reference Standard
HSN code	38229090
InChIKey	PMMYEEVYMWASQN-IUYQGCFVSA-N
SMILES	C1[C@@H](CN[C@H]1C(=O)O)O
PubChem CID	440074

Physical properties
Physical form	Solid
LogP (XLogP3)	-3.3
H-bond donors / acceptors	3 / 4
TPSA	69.6 Å²
Synonyms	H-D-Hyp-OH, (4S)-4-hydroxy-D-proline, trans-D-4-Hydroxyproline, D-Proline, 4-hydroxy-, (4S)-, D-Hyp-OH, (2R,4S)-4-Hydroxy-pyrrolidine-2-carboxylic acid, (2R,4S)-4-hydroxypyrrolidin-1-ium-2-carboxylate, d-hydroxyproline, trans-4-Hydroxy-D-proline (H-D-Hyp-OH), (2R,4S)-4-hydroxypyrrolidine-2-carboxylicacid, 4-(S)-hydroxypyrrolidine-2-(R)-carboxylic acid

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation

Precautionary statements: P233, P260, P261, P264, P264 + P265, P270, P271, P280, P284, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P342 + P316, P362 + P364, P403, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of trans-4-Hydroxy-D-proline?

The CAS Registry Number of trans-4-Hydroxy-D-proline is 3398-22-9. It is also known as H-D-Hyp-OH, (4S)-4-hydroxy-D-proline, trans-D-4-Hydroxyproline.

What is the molecular formula and molecular weight of trans-4-Hydroxy-D-proline?

trans-4-Hydroxy-D-proline has the molecular formula C5H9NO3 and a molecular weight of 131.13 g/mol. Its IUPAC name is (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid.

Which grade and pack sizes of trans-4-Hydroxy-D-proline can I order?

We supply trans-4-Hydroxy-D-proline in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with trans-4-Hydroxy-D-proline?

Yes. Every lot of trans-4-Hydroxy-D-proline is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can trans-4-Hydroxy-D-proline be shipped internationally?

Yes. trans-4-Hydroxy-D-proline is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.