Vemurafenib

Name: Vemurafenib
Brand: Vaqora Chemicals
SKU: VQ-034563

About Vemurafenib

Listed under CAS 918504-65-1, Vemurafenib is a high-purity reference standard of Vemurafenib available from Vaqora Chemicals. The compound has the formula C23H18ClF2N3O3S, corresponding to a molecular weight of 489.9 g/mol. The IUPAC name is N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide. Common synonyms include PLX-4032 and PLX 4032.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Vemurafenib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Vemurafenib is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Vemurafenib

View every impurity, metabolite and intermediate we list for Vemurafenib.

Vemurafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	Vemurafenib
Catalogue No.	VQ-034563
CAS Number	918504-65-1
IUPAC name	N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide
Molecular formula	C₂₃H₁₈ClF₂N₃O₃S
Molecular weight	489.9 g/mol
Exact mass	489.0725
Grade	Reference Standard
HSN code	38229090
InChIKey	GPXBXXGIAQBQNI-UHFFFAOYSA-N
SMILES	CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F
PubChem CID	42611257

Physical properties
Physical form	Solid
LogP (XLogP3)	5
H-bond donors / acceptors	2 / 7
TPSA	100 Å²
Synonyms	PLX-4032, PLX 4032, BRAF(V600E) Kinase Inhibitor RO5185426, BRAF (V600E) kinase inhibitor RO5185426, Vemurafenib (PLX4032, RG7204), Vemurafenib (PLX4032), EX-A053, PLX4032 (Vemurafenib), PLX4032 - Vemurafenib, 3og7

Safety & hazard information (GHS)

Environmental hazard

Signal word: Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P273, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Vemurafenib?

The CAS Registry Number of Vemurafenib is 918504-65-1. It is also known as PLX-4032, PLX 4032, BRAF(V600E) Kinase Inhibitor RO5185426.

What is the molecular formula and molecular weight of Vemurafenib?

Vemurafenib has the molecular formula C23H18ClF2N3O3S and a molecular weight of 489.9 g/mol. Its IUPAC name is N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide.

What is Vemurafenib used for?

Vemurafenib is supplied as a characterised reference material related to Vemurafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Vemurafenib can I order?

We supply Vemurafenib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Vemurafenib?

Yes. Every lot of Vemurafenib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Vemurafenib be shipped internationally?

Yes. Vemurafenib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.