VNL2 (Freebase)

Name: VNL2 (Freebase)
Brand: Vaqora Chemicals
SKU: VQ-013855

About VNL2 (Freebase)

VNL2 (Freebase) is a process intermediate or related compound of Venetoclax carrying the CAS registry number 1228780-72-0. Formula C19H27ClN2, molecular weight 318.9 g/mol. Its systematic (IUPAC) name is 1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazine. Alternative names: Abt199 int3 and Venetoclax Intermediate 1.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Process chemists and analysts use it when developing synthetic routes to Venetoclax, tracking process-related impurities and validating analytical methods. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, VNL2 (Freebase) is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Venetoclax

View every impurity, metabolite and intermediate we list for Venetoclax.

Venetoclax impurities

Specifications & identifiers

Chemical identifiers
Product name	VNL2 (Freebase)
Catalogue No.	VQ-013855
CAS Number	1228780-72-0
Other CAS	1628047-87-9
IUPAC name	1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazine
Molecular formula	C₁₉H₂₇ClN₂
Molecular weight	318.9 g/mol
Exact mass	318.1863
Grade	Reference Standard
HSN code	2933
InChIKey	YCNNHDUZLQPKJY-UHFFFAOYSA-N
SMILES	CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCNCC3)C
PubChem CID	66713599

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	1 / 2
TPSA	15.3 Å²
Synonyms	1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine, 1-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazine, 1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]piperazine, Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-, 1-((2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazine, 1-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine, Piperazine, 1-((2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl)methyl)-, 1-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine, Abt199 int3, Venetoclax Intermediate 1, 1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-piperazine, 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methy)piperazine

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of VNL2 (Freebase)?

The CAS Registry Number of VNL2 (Freebase) is 1228780-72-0. It is also known as 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine, 1-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazine, 1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]piperazine.

What is the molecular formula and molecular weight of VNL2 (Freebase)?

VNL2 (Freebase) has the molecular formula C19H27ClN2 and a molecular weight of 318.9 g/mol. Its IUPAC name is 1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazine.

What is VNL2 (Freebase) used for?

VNL2 (Freebase) is supplied as a characterised reference material related to Venetoclax. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of VNL2 (Freebase) can I order?

We supply VNL2 (Freebase) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with VNL2 (Freebase)?

Yes. Every lot of VNL2 (Freebase) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can VNL2 (Freebase) be shipped internationally?

Yes. We export VNL2 (Freebase) worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.